Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | HRH2 | P25021 | 6/20 | 0.43 |
| ▸ | HRH1 | P35367 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL106768 | 1.00 | TLR8 (0.54) | TLR8CNR2USP2SMN1; SMN2CHRM2 | |
| SCHEMBL29129466 | 0.98 | TLR8 (0.53) | TLR8CNR2USP2SMN1; SMN2CHRM2 | |
| SCHEMBL4543892 | 0.95 | TLR8 (0.55) | TLR8CNR2USP2SMN1; SMN2CHRM2 | |
| SCHEMBL8253901 | 0.92 | USP2 (0.51) | TLR8USP2SMN1; SMN2CHRM2CHRM1 | |
| Pyrazine SCHEMBL28467340 | 0.92 | TLR8 (0.51) | TLR8CNR2CHRM2CHRM1CHRM4 | |
| SCHEMBL20873847 | 0.90 | USP2 (0.53) | TLR8USP2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL2616174 | 0.88 | USP2 (0.51) | TLR8USP2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL27097882 | 0.88 | TLR8 (0.50) | TLR8EPHX2HRH2HRH1 | |
| SCHEMBL12193455 | 0.87 | USP2 (0.47) | TLR8USP2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL8242595 | 0.86 | USP2 (0.61) | TLR8USP2SMN1; SMN2CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0595924-B1 | PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LAB (US) | 1999-04-14 | — | — | EP | claimed |