Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 12/20 | 0.35 |
| ▸ | RHEB | Q15382 | 2/20 | 0.35 |
| ▸ | HTR1D | P28221 | 4/20 | 0.34 |
| ▸ | HTR1B | P28222 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL827421 | 0.90 | CTRC (0.39) | P2RX7RHEBHTR1DHTR1B | |
| SCHEMBL8528724 | 0.85 | P2RX7 (0.40) | P2RX7RHEB | |
| SCHEMBL38650836 | 0.84 | P2RX7 (0.36) | P2RX7RHEB | |
| SCHEMBL19014172 | 0.79 | P2RX7 (0.38) | P2RX7RHEB | |
| SCHEMBL19014001 | 0.78 | P2RX7 (0.41) | P2RX7RHEB | |
| SCHEMBL29443976 | 0.74 | AHR (0.47) | HTR1B | |
| SCHEMBL1754917 | 0.74 | AHR (0.47) | HTR1B | |
| SCHEMBL14216334 | 0.72 | TYR (0.39) | HTR1DHTR1B | |
| Tert-Butyl Formate SCHEMBL27800475 | 0.72 | P2RX7 (0.35) | P2RX7 | |
| SCHEMBL15826672 | 0.71 | P2RX7 (0.39) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834494-A | SEROTONIN 5HT2B/2C RECEPTOR ANTAGONISTS; CNS NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS; IRRITABLE BOWEL SYNDROME | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-11-10 | — | — | US | disclosed |
| EP-0707581-B1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-02-26 | — | — | EP | disclosed |
| CN-1129937-A | Indoline derivatives as 5HT2C antagonists | SMITHKLINE BEECHAM PLC (GB) | 1996-08-28 | — | — | CN | disclosed |
| EP-0707581-A1 | INDOLINE DERIVATIVES AS 5HT 2C? ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995001976-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-01-19 | — | — | WO | disclosed |