Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 3/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8475138 | 0.86 | KMT2A (0.64) | MEN1KMT2AGAALMNAPOLB | |
| SCHEMBL8527236 | 0.83 | MEN1 (0.56) | MEN1KMT2AGAAL3MBTL1HTR2B | |
| SCHEMBL8684762 | 0.79 | MEN1 (0.51) | MEN1KMT2AGAAL3MBTL1HTR2B | |
| SCHEMBL8584049 | 0.76 | KMT2A (0.61) | MEN1KMT2AGAALMNAPOLB | |
| SCHEMBL8526757 | 0.75 | MEN1 (0.50) | MEN1KMT2AGAAL3MBTL1POLB | |
| SCHEMBL8479289 | 0.72 | KMT2A (0.70) | MEN1KMT2AGAAL3MBTL1LMNA | |
| SCHEMBL7653034 | 0.69 | P2RX7 (0.36) | MEN1KMT2AMAPK8MAPK10L3MBTL1 | |
| SCHEMBL8915225 | 0.68 | KMT2A (0.64) | MEN1KMT2AGAALMNAPOLB | |
| SCHEMBL9081577 | 0.67 | — | — | |
| SCHEMBL8663001 | 0.66 | MEN1 (0.58) | MEN1KMT2AGAAL3MBTL1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5807864-A | INCREASING HIGH DENSITY LIPOPROTEIN LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-15 | — | — | US | claimed |
| EP-0885197-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | EP | disclosed |
| US-5807864-A | INCREASING HIGH DENSITY LIPOPROTEIN LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-15 | — | — | US | disclosed |
| WO-1997032855-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-12 | — | — | WO | disclosed |