Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8527236 | 0.91 | MEN1 (0.56) | MEN1KMT2AGAAL3MBTL1POLB | |
| SCHEMBL8665062 | 0.87 | MEN1 (0.62) | MEN1KMT2AGAAP2RX7 | |
| SCHEMBL8584049 | 0.86 | KMT2A (0.61) | MEN1KMT2AGAAP2RX7POLB | |
| SCHEMBL9013933 | 0.78 | KMT2A (0.53) | MEN1KMT2AGAAP2RX7L3MBTL1 | |
| SCHEMBL8684762 | 0.78 | MEN1 (0.51) | MEN1KMT2AGAAP2RX7L3MBTL1 | |
| SCHEMBL8714673 | 0.78 | MEN1 (0.57) | MEN1KMT2AGAAP2RX7ALDH1A1 | |
| SCHEMBL8479289 | 0.76 | KMT2A (0.70) | MEN1KMT2AGAAL3MBTL1POLB | |
| SCHEMBL8526296 | 0.75 | MEN1 (0.51) | MEN1KMT2AGAAL3MBTL1POLB | |
| SCHEMBL7653392 | 0.75 | P2RX7 (0.39) | MEN1KMT2AP2RX7L3MBTL1POLB | |
| SCHEMBL8527399 | 0.74 | KMT2A (0.43) | MEN1KMT2AGAAP2RX7POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885197-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | EP | claimed |
| US-5807864-A | INCREASING HIGH DENSITY LIPOPROTEIN LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-15 | — | — | US | claimed |
| WO-1997032855-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-12 | — | — | WO | claimed |
| EP-0885197-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | EP | disclosed |
| US-5807864-A | INCREASING HIGH DENSITY LIPOPROTEIN LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-15 | — | — | US | disclosed |
| WO-1997032855-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-12 | — | — | WO | disclosed |