SCHEMBL8526945

SCHEMBL8526945

CNc1ccc(-c2ccc(NC)cc2C#N)cc1

nearest known ligand 0.40

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
APP P05067 1/20 0.39
ALDH1A1 P00352 3/20 0.39
MAPT P10636 1/20 0.39
GRM2 Q14416 1/20 0.38
ESR2 Q92731 1/20 0.38
STS P08842 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
MAPK1 P28482 1/20 0.38
HSD17B10 Q99714 1/20 0.38
CLK4 Q9HAZ1 1/20 0.38
CHKA P35790 1/20 0.37
KIF11 P52732 1/20 0.36
PRKCQ Q04759 1/20 0.36
PGR P06401 1/20 0.36
XDH P47989 1/20 0.35
CYP19A1 P11511 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8701871 0.81 ESR2 (0.59) ALDH1A1MAPTESR2CYP1A2CYP3A4
SCHEMBL14046649 0.78 ALDH1A1 (0.46) ALDH1A1MAPT
SCHEMBL20112613 0.75 ALDH1A1 (0.46) ALDH1A1ESR2CYP1A2CYP3A4MAPK1
SCHEMBL21966924 0.75 TSHR (0.45) APPALDH1A1MAPT
SCHEMBL3173181 0.75 GRM4 (0.48) ALDH1A1MAPTPGR
SCHEMBL8343255 0.73 SLC22A12 (0.50) ALDH1A1MAPT
SCHEMBL9586755 0.73 CYP1A2 (0.43) APPALDH1A1MAPTCYP1A2CYP3A4
SCHEMBL18356521 0.73 GRM2 (0.33) APPALDH1A1GRM2ESR2CYP1A2
SCHEMBL13207193 0.71 PDE3B (0.43) APPALDH1A1MAPTGRM2CYP1A2
SCHEMBL12117937 0.71 ABCG2 (0.46) ALDH1A1MAPTPGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0570250-B1 Crystalline structure of monohydrogentartrates, process for its preparation and application thereof FRANCE TELECOM (FR) 1998-06-03 EP disclosed
EP-0619308-B1 Crystalline structures of halides of 2-amino-5-nitro-pyridinium, process for their preparation and an electrooptical device with such structures FRANCE TELECOM (FR) 1998-03-11 EP disclosed
US-5637717-A 2-amino-5-nitropyridinium halide crystal structure and process for the preparation of said crystal structures FRANCE TELECOM (FR) 1997-06-10 US disclosed
US-5514807-A 5-amino-5-nitropyridinium halide crystal structure FRANCE TELECOM (FR) 1996-05-07 US disclosed
US-5374734-A Monohydrogentartrate crystalline structure having nonlinear quadratic effects FRANCE TELECOM (FR) 1994-12-20 US disclosed
EP-0619308-A1 Crystalline structures of the hydrogen chloride salt of 2-amino-5-nitro-pyridinium, process for their preparation and an electrooptical device with such structures FRANCE TELECOM (FR) 1994-10-12 EP disclosed
EP-0570250-A2 Crystalline structure of monohydrogentartrates, process for its preparation and application thereof FRANCE TELECOM (FR) 1993-11-18 EP disclosed