Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | AHR | P35869 | 6/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 5/20 | 0.43 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | F7 | P08709 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | F3 | P13726 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8526792 | 0.86 | CSNK2A1 (0.55) | CSNK2A1AHRNR4A2CMA1F7 | |
| SCHEMBL31201815 | 0.84 | CSNK2A1 (0.53) | CSNK2A1AHRNR4A2CMA1F7 | |
| SCHEMBL14722496 | 0.79 | CSNK2A1 (0.55) | CSNK2A1AHRNR4A2CMA1F7 | |
| SCHEMBL9004441 | 0.79 | CSNK2A1 (0.50) | CSNK2A1AHRNR4A2CMA1F7 | |
| SCHEMBL613747 | 0.75 | CSNK2A1 (0.69) | CSNK2A1AHRNR4A2CMA1F7 | |
| SCHEMBL10289632 | 0.74 | GPR84 (0.48) | CSNK2A1AHRNR4A2CMA1F7 | |
| Tert-Butyl Formate SCHEMBL27779443 | 0.72 | CSNK2A1 (0.41) | CSNK2A1AHRNR4A2CMA1F7 | |
| SCHEMBL615624 | 0.72 | CSNK2A1 (0.60) | CSNK2A1AHRNR4A2CMA1F7 | |
| SCHEMBL27447560 | 0.71 | CSNK2A1 (0.50) | CSNK2A1AHRNR4A2CMA1F7 | |
| SCHEMBL8526222 | 0.71 | CSNK2A1 (0.55) | CSNK2A1AHRNR4A2CMA1F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834494-A | SEROTONIN 5HT2B/2C RECEPTOR ANTAGONISTS; CNS NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS; IRRITABLE BOWEL SYNDROME | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-11-10 | — | — | US | disclosed |
| EP-0707581-B1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-02-26 | — | — | EP | disclosed |
| CN-1129937-A | Indoline derivatives as 5HT2C antagonists | SMITHKLINE BEECHAM PLC (GB) | 1996-08-28 | — | — | CN | disclosed |
| EP-0707581-A1 | INDOLINE DERIVATIVES AS 5HT 2C? ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995001976-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-01-19 | — | — | WO | disclosed |