Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDAH1 | O94760 | 3/20 | 0.53 |
| ▸ | NOS1 | P29475 | 6/20 | 0.50 |
| ▸ | OTC | P00480 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 5/20 | 0.44 |
| ▸ | NOS3 | P29474 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitroarginine SCHEMBL14220319 | 1.00 | DDAH1 (0.53) | DDAH1NOS1OTCNOS2NOS3 | |
| Nitroarginine SCHEMBL8527851 | 1.00 | DDAH1 (0.53) | DDAH1NOS1OTCNOS2NOS3 | |
| Nitroarginine SCHEMBL12556124 | 1.00 | DDAH1 (0.53) | DDAH1NOS1OTCNOS2NOS3 | |
| Nitroarginine SCHEMBL6054201 | 0.94 | OTC (0.52) | DDAH1NOS1OTCNOS2NOS3 | |
| L-Name SCHEMBL29362113 | 0.84 | NOS1 (0.41) | DDAH1NOS1OTCTSHR | |
| L-Name SCHEMBL5966636 | 0.84 | NOS1 (0.41) | DDAH1NOS1OTCTSHR | |
| SCHEMBL12556111 | 0.84 | NOS1 (0.46) | DDAH1NOS1OTCNOS2NOS3 | |
| Hydrochloric Acid SCHEMBL7365158 | 0.83 | DDAH1 (0.38) | DDAH1NOS1OTCNOS2NOS3 | |
| SCHEMBL14350781 | 0.83 | NOS1 (0.40) | DDAH1NOS1OTCNOS2NOS3 | |
| SCHEMBL12237928 | 0.81 | NOS1 (0.36) | DDAH1NOS1NOS3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885186-A1 | AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997019911-A1 | AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1997-06-05 | — | — | WO | disclosed |