Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | GLP1R | P43220 | 5/20 | 0.32 |
| ▸ | SCTR | P47872 | 1/20 | 0.32 |
| ▸ | GRM8 | O00222 | 1/20 | 0.32 |
| ▸ | GRM6 | O15303 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.32 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL8528151 | 1.00 | GSR (0.36) | GSRMC4RALOX15BLMPMP22 | |
| Arginine SCHEMBL25294109 | 0.97 | GSR (0.38) | GSRMC4RALOX15BLMPMP22 | |
| Arginine SCHEMBL8314691 | 0.97 | GSR (0.38) | GSRMC4RTHRBGRM8GRM6 | |
| Arginine SCHEMBL29263954 | 0.93 | GSR (0.42) | GSRTHRBC5AR1TUBB4ATUBB | |
| Arginine SCHEMBL14764665 | 0.93 | GSR (0.42) | GSRTHRBC5AR1TUBB4ATUBB | |
| Arginine SCHEMBL28491547 | 0.93 | GSR (0.42) | GSRTHRBC5AR1TUBB4ATUBB | |
| Arginine SCHEMBL693611 | 0.93 | GSR (0.42) | GSRTHRBC5AR1TUBB4ATUBB | |
| Arginine SCHEMBL1063567 | 0.93 | GSR (0.42) | GSRTHRBC5AR1TUBB4ATUBB | |
| Arginine SCHEMBL27941089 | 0.93 | ALOX15 (0.40) | ALOX15BLMPMP22KMT2ACYP1A2 | |
| Arginine SCHEMBL15140975 | 0.93 | GRM8 (0.38) | GSRALOX15BLMPMP22KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873304-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1998-10-28 | — | — | EP | disclosed |
| WO-1997019053-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-05-29 | — | — | WO | disclosed |