SCHEMBL8528469

SCHEMBL8528469

O=C(O)Cc1c[nH]c2c(Cl)cc(Cl)cc12

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR17 Q13304 1/20 0.46
TSHR P16473 2/20 0.45
LMNA P02545 2/20 0.45
ALDH1A1 P00352 2/20 0.45
GLA P06280 1/20 0.45
CYP2C9 P11712 1/20 0.45
HPGD P15428 1/20 0.45
NFKB1 P19838 1/20 0.45
PMP22 Q01453 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
KDM4E B2RXH2 2/20 0.41
KEAP1 Q14145 1/20 0.41
NFE2L2 Q16236 1/20 0.41
PTGS2 P35354 1/20 0.40
MAPT P10636 2/20 0.39
PKM P14618 1/20 0.39
CHRM1 P11229 1/20 0.38
CSNK2A2 P19784 1/20 0.38
CSNK2B P67870 1/20 0.38
CSNK2A1 P68400 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6512206 0.84 TSHR (0.49) GPR17TSHRLMNAALDH1A1GLA
SCHEMBL25498027 0.80 AR (0.39) GPR17TSHRLMNAALDH1A1KDM4E
SCHEMBL26693263 0.78 TNF (0.61) GPR17TSHRLMNAALDH1A1CYP2C9
SCHEMBL26693262 0.78 TNF (0.61) GPR17TSHRLMNAALDH1A1CYP2C9
SCHEMBL32684009 0.78 TNF (0.61) GPR17TSHRLMNAALDH1A1CYP2C9
SCHEMBL6516641 0.77 HTR2A (0.58) TSHRLMNAALDH1A1GLACYP2C9
SCHEMBL23623627 0.76 F7 (0.54) TSHRALDH1A1HPGDCSNK2A2CSNK2B
SCHEMBL30416712 0.76 F7 (0.54) TSHRALDH1A1HPGDCSNK2A2CSNK2B
SCHEMBL9755991 0.75 CSNK2A2 (0.56) GPR17TSHRLMNAALDH1A1GLA
SCHEMBL27858184 0.75 KEAP1 (0.39) GPR17TSHRLMNAALDH1A1GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115850123-B Preparation method of 2, 4-dichloroaniline/hydrazine 山东潍坊润丰化工股份有限公司 2024-04-19 CN disclosed
CN-115850123-A Preparation method of 2, 4-dichloroaniline/hydrazine 山东潍坊润丰化工股份有限公司 2023-03-28 CN disclosed
CN-103621505-A Application of halogenated indole-3-acetic acid as herbicide UNIV SOUTHEAST 2014-03-12 CN disclosed
EP-0652212-B1 Substituted fluorine-containing beta-indolebutyric acid derivatives, their preparation and their use as plant growth regulators AGENCY IND SCIENCE TECHN (JP) 1998-03-11 EP disclosed
US-5496794-A CONTROLLING LENGTH OF SPROUTING ROOTS, ADHESION TO SEEDS AGENCY OF INDUSTRIAL SCIENCE & TECHNOLOGY (JP) 1996-03-05 US disclosed
EP-0652212-A1 Substituted fluorine-containing beta-indolebutyric acid derivatives, their preparation and their use as plant growth regulators Agency of Industrial Science and Technology of Ministry of International Trade and Industry (JP) 1995-05-10 EP disclosed
EP-0256128-B1 INDOLEACETIC ACID DERIVATIVES AND USE THEREOF AS PLANT GROWTH REGULATORS NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1991-11-06 EP disclosed
US-4806143-A Indoleacetic acid derivatives and application thereof as plant growth regulators NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1989-02-21 US disclosed
EP-0256128-A1 INDOLEACETIC ACID DERIVATIVES AND USE THEREOF AS PLANT GROWTH REGULATORS NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1988-02-24 EP disclosed