SCHEMBL852879

SCHEMBL852879

COC(=O)c1cc(Cl)c(Cl)cc1C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.51
POLB P06746 2/20 0.46
ABL1 P00519 1/20 0.46
TSHR P16473 1/20 0.46
MEN1 O00255 3/20 0.45
KMT2A Q03164 3/20 0.45
LMNA P02545 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
HTT P42858 2/20 0.44
KDM4E B2RXH2 2/20 0.44
SORT1 Q99523 5/20 0.43
HSD17B10 Q99714 1/20 0.42
CA12 O43570 2/20 0.41
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA7 P43166 2/20 0.41
CA9 Q16790 2/20 0.41
CA14 Q9ULX7 2/20 0.41
PDK2 Q15119 1/20 0.41
PDK4 Q16654 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1953848 0.91 GAA (0.58) GAAABL1TSHRMEN1KMT2A
SCHEMBL11222239 0.88 GAA (0.51) GAAPOLBABL1TSHRMEN1
SCHEMBL828778 0.87 CA12 (0.47) GAAPOLBABL1TSHRLMNA
SCHEMBL337450 0.87 CA12 (0.47) GAAPOLBABL1TSHRLMNA
SCHEMBL25515986 0.87 CA12 (0.47) GAAPOLBABL1TSHRLMNA
SCHEMBL829544 0.87 CA12 (0.47) GAAPOLBABL1TSHRLMNA
SCHEMBL29869709 0.87 CA12 (0.47) GAAPOLBABL1TSHRLMNA
SCHEMBL10616295 0.87 CA12 (0.47) GAAPOLBABL1TSHRLMNA
Hydrochloric Acid SCHEMBL6380287 0.85 CA12 (0.45) GAAPOLBABL1TSHRLMNA
SCHEMBL852553 0.83 GAA (0.51) GAAABL1MEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260132112-A1 COMPOUNDS CTXT PTY LTD (AU) 2026-05-14 US disclosed
EP-4077318-B1 BENZIMIDAZOLE DIMERS AS MODULATORS OF STING CTXT PTY LTD (AU) 2025-10-15 EP disclosed
US-12415785-B2 Compound modulators of sting CTXT PTY LTD (AU) 2025-09-16 US disclosed
CN-114981265-B Compounds of formula (I) CTXT私人有限公司 2025-01-03 CN disclosed
US-20230062932-A1 COMPOUNDS CTXT PTY LTD. (AU) 2023-03-02 US disclosed
US-20230062932-A1 COMPOUNDS CTXT PTY LTD. (AU) 2023-03-02 US disclosed
WO-2022266711-A1 SUBSTITUTED AMIDOBENZIMIDAZOLE DIMERS AS STING MODULATORS Aculeus Therapeutics Pty Ltd (AU) 2022-12-29 WO disclosed
WO-2022266711-A1 SUBSTITUTED AMIDOBENZIMIDAZOLE DIMERS AS STING MODULATORS Aculeus Therapeutics Pty Ltd (AU) 2022-12-29 WO disclosed
EP-4077318-A1 COMPOUNDS CTXT PTY LTD (AU) 2022-10-26 EP disclosed
CN-114981265-A Compound (I) CTXT私人有限公司 2022-08-30 CN disclosed
US-20050043310-A1 Preparation of quinoxaline compounds JANSSEN PHARMACEUTICA, N.V. (BE) 2005-02-24 US disclosed
US-20050038032-A1 Quinoxaline compounds JANSSEN PHARMACEUTICA, N.V. (BE) 2005-02-17 US disclosed
WO-2004089897-A1 COMPOUNDS HAVING ACTIVITY AT 5HT2C RECEPTOR AND USES THEREOF GLAXO GROUP LIMITED (GB) 2004-10-21 WO disclosed
US-5750545-A EXHIBIT EOSINOPHIL-INHIBITORY ACTION AND LYMPHOCYTE ACTIVATION-INHIBITORY ACTION; USEFUL FOR TREATMENT OF IMMUNE-RELATED DISEASES THE GREEN CROSS CORPORATION (JP) 1998-05-12 US disclosed
EP-0825187-A1 Condensed pyridazinyl guanidines, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-02-25 EP disclosed
EP-0710654-A1 TRIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF THE GREEN CROSS CORPORATION (JP) 1996-05-08 EP disclosed
US-5175164-A Hypotensive agents MERCK & CO., INC. (US) 1992-12-29 US disclosed
EP-0517357-A1 Angiotensin II antagonists incorporating a substituted indole or dihydroindole MERCK & CO. INC. (US) 1992-12-09 EP disclosed
EP-0508723-A1 Angiotensin II antagonists incorporating an indole or dihydroindole MERCK & CO. INC. (US) 1992-10-14 EP disclosed
US-5151435-A Hypotensive agents, glaucoma and cognition activators MERCK & CO., INC. (US) 1992-09-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050043310-A1 Preparation of quinoxaline compounds CCKAR, CCKBR, GIPR GAA 1615/4885POLB 3802/4885ABL1 1011/4885
US-12415785-B2 Compound modulators of sting STING1, IRF3, MAVS GAA 572/4885POLB 1735/4885ABL1 2874/4885
US-20260132112-A1 COMPOUNDS STING1, IRF3, CGAS GAA 2456/4885POLB 1166/4885ABL1 2303/4885
US-20050038032-A1 Quinoxaline compounds CCKAR, CCKBR, GIPR GAA 1879/4885POLB 4318/4885ABL1 763/4885
US-20230062932-A1 COMPOUNDS STING1, IRF3, MAVS GAA 337/4885POLB 1666/4885ABL1 2459/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.