SCHEMBL8528995

SCHEMBL8528995

COc1ccc(OC)c2c1COC(OC=O)C2

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ADRA1A P35348 4/20 0.43
ACHE P22303 3/20 0.37
PTPRF P10586 1/20 0.36
CYP1A2 P05177 1/20 0.34
ALDH1A1 P00352 3/20 0.33
KDM4E B2RXH2 1/20 0.33
GLA P06280 1/20 0.33
GAA P10253 1/20 0.33
HPGD P15428 1/20 0.33
POLL Q9UGP5 1/20 0.33
TSHR P16473 1/20 0.32
ALDH1A3 P47895 1/20 0.31
CHRM2 P08172 1/20 0.31
CHRM1 P11229 1/20 0.31
CHRM3 P20309 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8903286 0.78 ADRA1A (0.46) ADRA1AACHEPTPRFCYP1A2ALDH1A1
SCHEMBL9520663 0.77 ADRA1A (0.31) ADRA1A
SCHEMBL9520657 0.75 ADRA1A (0.40) ADRA1AACHEPTPRFALDH1A1KDM4E
SCHEMBL8529148 0.74 ADRA1A (0.39) ADRA1AACHEPTPRFALDH1A1KDM4E
SCHEMBL9522309 0.72 ADRA1A (0.37) ADRA1AACHEPTPRFCYP1A2ALDH1A1
SCHEMBL9522184 0.72 ADRA1A (0.38) ADRA1AACHEPTPRFCHRM2CHRM1
SCHEMBL8529815 0.71 ADRA1A (0.46) ADRA1AACHECYP1A2ALDH1A1KDM4E
SCHEMBL8527137 0.70 MIF (0.45) ADRA1AACHECYP1A2ALDH1A1KDM4E
SCHEMBL8527470 0.70 CYP1A2 (0.47) ADRA1AACHECYP1A2ALDH1A1HPGD
SCHEMBL8527972 0.70 ADRA1A (0.41) ADRA1AACHECYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0533744-A1 HETEROCYCLIC ANTHRACYCLIONE AND ANTHRACYCLINE ANALOGS BIOCHEM PHARMA INC. (CA) 1993-03-31 EP claimed
WO-1991019725-A2 HETEROCYCLIC ANTHRACYCLIONE AND ANTHRACYCLINE ANALOGS BIOCHEM PHARMA INC. (CA) 1991-12-26 WO claimed
US-5736523-A ADMINISTERING TO THE MAMMAL SUFFERING FROM CANCER BIOCHEM PHARMA INC. (CA) 1998-04-07 US disclosed
US-5606037-A Processes antineoplastic heteronaphthoquinones BIOCHEM PHARMA INC. (CA) 1997-02-25 US disclosed
US-5593970-A ANTITUMOR AND ANTCARCINOGENIC AGENTS; TRETMENT OF CANCEROUS BONE MARROW BEFORE REGRAFTING BIOCHEM PHARMA INC. (CA) 1997-01-14 US disclosed
EP-0659190-A1 ANTINEOPLASTIC HETERONAPHTHOQUINONES BIOCHEM PHARMA INC (CA) 1995-06-28 EP disclosed
WO-1995012588-A1 ANTINEOPLASTIC HETERONAPHTHOQUINONES BIOCHEM PHARMA INC. (CA) 1995-05-11 WO disclosed
WO-1994011382-A1 ANTINEOPLASTIC HETERONAPHTHOQUINONES BIOCHEM PHARMA INC. (CA) 1994-05-26 WO disclosed
CN-1058781-A New heterocyclic anthracycline hydrocarbon homologue IAF BIOCHEM INT (CA) 1992-02-19 CN disclosed