Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | STING1 | Q86WV6 | 11/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1316410 | 0.86 | KDM4E (0.49) | KDM4EHSD17B10STING1ALDH1A1ALOX15 | |
| SCHEMBL7542359 | 0.81 | STING1 (0.48) | STING1MEN1MAPTPKMGRIK1 | |
| SCHEMBL7988850 | 0.81 | PTPN1 (0.59) | STING1 | |
| SCHEMBL1317174 | 0.81 | ACLY (0.64) | KDM4EHSD17B10ALDH1A1HDAC1CASP1 | |
| SCHEMBL5167381 | 0.81 | SMN1; SMN2 (0.52) | KDM4EHSD17B10ALDH1A1POLBMEN1 | |
| SCHEMBL28544472 | 0.81 | SMN1; SMN2 (0.52) | KDM4EHSD17B10ALDH1A1POLBMEN1 | |
| SCHEMBL1645001 | 0.79 | HDAC1 (0.53) | KDM4EHSD17B10ALDH1A1HDAC1HDAC6 | |
| SCHEMBL13893513 | 0.79 | KDM4E (0.41) | KDM4EHSD17B10ALDH1A1ALOX15HDAC1 | |
| SCHEMBL8530089 | 0.78 | KDM4E (0.56) | KDM4EHSD17B10ALDH1A1ALOX15POLB | |
| SCHEMBL9374442 | 0.78 | KDM4E (0.56) | KDM4EHSD17B10ALDH1A1ALOX15HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5783577-A | COMBINATORIAL LIBRARY FOR DRUG SCREENING | TREGA BIOSCIENCES, INC. (US) | 1998-07-21 | — | — | US | disclosed |
| WO-1998011438-A1 | SYNTHESIS OF QUINAZOLINONE LIBRARIES AND DERIVATIVES THEREOF | TREGA BIOSCIENCES, INC. (US) | 1998-03-19 | — | — | WO | disclosed |
| WO-1997010221-A1 | SYNTHESIS OF QUINAZOLINONE LIBRARIES | TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (US) | 1997-03-20 | — | — | WO | disclosed |