Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8530581 | 0.86 | ALDH1A1 (0.53) | ALDH1A1LMNANPSR1L3MBTL1HTT | |
| SCHEMBL12843990 | 0.84 | ALDH1A1 (0.72) | ALDH1A1LMNANPSR1L3MBTL1HTT | |
| SCHEMBL24185685 | 0.82 | ALDH1A1 (0.55) | ALDH1A1LMNANPSR1L3MBTL1HTT | |
| SCHEMBL14438050 | 0.82 | ALDH1A1 (0.57) | ALDH1A1LMNANPSR1L3MBTL1GAA | |
| SCHEMBL156901 | 0.81 | HTT (0.60) | ALDH1A1LMNANPSR1L3MBTL1HTT | |
| SCHEMBL4209751 | 0.79 | ALDH1A1 (0.62) | ALDH1A1LMNANPSR1L3MBTL1HTT | |
| SCHEMBL24240347 | 0.79 | ALDH1A1 (0.49) | ALDH1A1LMNANPSR1L3MBTL1HTT | |
| SCHEMBL4211669 | 0.78 | MAPT (0.56) | ALDH1A1LMNANPSR1L3MBTL1HTT | |
| SCHEMBL10673993 | 0.77 | HSD11B1 (0.46) | ALDH1A1LMNANPSR1L3MBTL1HTT | |
| SCHEMBL4200649 | 0.76 | PRMT1 (0.63) | ALDH1A1LMNANPSR1L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1061041-C | Piperidine derivatives | GLAXO GROUP LTD (GB) | 2001-01-24 | — | — | CN | disclosed |
| US-5843966-A | Piperidine derivatives | GLAXO GROUP LIMITED (GB) | 1998-12-01 | — | — | US | disclosed |
| EP-0720609-B1 | 3-(5-TETRAZOLYL-BENZYL)AMINO-PIPERIDINE DERIVATIVES AND ANTAGONISTS OF TACHYKININS | GLAXO GROUP LTD (GB) | 1998-11-11 | — | — | EP | disclosed |
| US-5703240-A | ANALGESICS; ANTIINFLAMMATORY AGENTS; NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS; GASTROINTESTINAL DISORDERS | GLAXO GROUP LIMITED (GB) | 1997-12-30 | — | — | US | disclosed |
| CN-1135218-A | Piperidine derivatives | GLAXO GROUP LTD (GB) | 1996-11-06 | — | — | CN | disclosed |
| EP-0720609-A1 | 3-(5-TETRAZOLYL-BENZYL)AMINO-PIPERIDINE DERIVATIVES AND ANTAGONISTS OF TACHYKININS | GLAXO GROUP LIMITED (GB) | 1996-07-10 | — | — | EP | disclosed |
| WO-1995008549-A1 | 3-(5-TETRAZOLYL-BENZYL)AMINO-PIPERIDINE DERIVATIVES AND ANTAGONISTS OF TACHYKININS | GLAXO GROUP LIMITED (GB) | 1995-03-30 | — | — | WO | disclosed |