Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL420971 | 1.00 | MAPT (0.56) | MAPTSOS1MAOBCYP19A1STAT3 | |
| SCHEMBL7298528 | 0.85 | TSHR (0.50) | MAPTSOS1MAOBCYP19A1STAT3 | |
| SCHEMBL11006035 | 0.85 | TSHR (0.50) | MAPTSOS1MAOBCYP19A1STAT3 | |
| SCHEMBL24464120 | 0.83 | ALDH1A1 (0.52) | MAPTSOS1MAOBCYP19A1STAT3 | |
| SCHEMBL9978289 | 0.82 | MAPT (0.69) | MAPTSOS1MAOBCYP19A1ALDH1A1 | |
| SCHEMBL11049170 | 0.82 | MAPT (0.69) | MAPTSOS1MAOBCYP19A1ALDH1A1 | |
| SCHEMBL14935499 | 0.82 | MAPT (0.69) | MAPTSOS1MAOBCYP19A1ALDH1A1 | |
| SCHEMBL8534442 | 0.81 | ALDH1A1 (0.54) | MAPTSOS1MAOBCYP19A1STAT3 | |
| SCHEMBL8534445 | 0.81 | ALDH1A1 (0.54) | MAPTSOS1MAOBCYP19A1STAT3 | |
| SCHEMBL11296000 | 0.81 | MAPT (0.67) | MAPTSOS1MAOBCYP19A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4394514-A | Processes for preparing 4-substituted indoles | SMITHKLINE BECKMAN CORPORATION (US) | 1983-07-19 | — | — | US | claimed |
| JP-60025957-A | — | — | None | — | — | JP | disclosed |
| CN-107295798-A | Benzazepine dicarboxamide compound | 豪夫迈·罗氏有限公司 | 2017-10-24 | — | — | CN | disclosed |
| CN-102746211-B | Method for preparing substituted indole-3-methanal compound | Shanghai titan chemical co ltd | 2015-05-27 | — | — | CN | disclosed |
| CN-102746211-A | Method for preparing substituted indole-3-methanal compound | Shanghai titan chemical co ltd | 2012-10-24 | — | — | CN | disclosed |
| EP-0489547-B1 | A process for the preparation of a 3-alkylated indole, intermediates, and a process for the preparation of a derivative thereof | ZENECA LTD (GB) | 1998-07-29 | — | — | EP | disclosed |
| US-5280125-A | Chemical process for the preparation of 3-alkylated indole | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-01-18 | — | — | US | disclosed |
| EP-0430001-B1 | Process for preparing benzaldehydes | BAYER AG (DE) | 1993-12-22 | — | — | EP | disclosed |
| US-5260339-A | 4-phenyl-1,3-benzodiazepines and 2-amino-α-phenylphenethylamines for treating convulsions and protecting neurons | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-11-09 | — | — | US | disclosed |
| US-5185465-A | Carboxamides of 2-amino-alpha-phenlphenethylamines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-02-09 | — | — | US | disclosed |
| US-4459230-A | Process for preparing 4-phenyl-1,3-benzodiazepines | HOECHST-ROUSSEL PHARMACEUTICALS, INCORPORATED (US) | 1984-07-10 | — | — | US | disclosed |
| US-4459231-A | Process for preparing 4-phenyl-1,3-benzodiazepines | HOECHST-ROUSSEL PHARMACEUTICALS, INCORPORATED (US) | 1984-07-10 | — | — | US | disclosed |
| US-4454337-A | Semicarbazide intermediates for preparing 4-substituted indoles | SMITHKLINE BECKMAN CORPORATION (US) | 1984-06-12 | — | — | US | disclosed |
| US-4409145-A | OXIMINATION, ESTERIFICATION, REDUCTION | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1983-10-11 | — | — | US | disclosed |
| US-4394514-A | Processes for preparing 4-substituted indoles | SMITHKLINE BECKMAN CORPORATION (US) | 1983-07-19 | — | — | US | disclosed |
| US-4394514-A | Processes for preparing 4-substituted indoles | SMITHKLINE BECKMAN CORPORATION (US) | 1983-07-19 | — | — | US | disclosed |
| US-4309424-A | 4-Phenyl-1,3-benzodiazepines | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1982-01-05 | — | — | US | disclosed |
| US-3979410-A | Intermediate α-acyl-β-dialkylamino-2-nitrostyrenes | HOFFMANN-LA ROCHE INC. (US) | 1976-09-07 | — | — | US | disclosed |
| US-3976639-A | Intermediates for indoles | HOFFMANN-LA ROCHE INC. (US) | 1976-08-24 | — | — | US | disclosed |
| US-3931225-A | Process for preparing o-nitrobenzylketones | HOFFMANN-LA ROCHE INC. (US) | 1976-01-06 | — | — | US | disclosed |