Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | HTR5A | P47898 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7041746 | 0.95 | SIGMAR1 (0.54) | SIGMAR1TMEM97ADRA2AADRA2BADRA2C | |
| SCHEMBL31514906 | 0.80 | SIGMAR1 (0.54) | SIGMAR1TMEM97ADRA2AADRA2BADRA2C | |
| SCHEMBL1206388 | 0.80 | SIGMAR1 (0.54) | SIGMAR1TMEM97ADRA2AADRA2BADRA2C | |
| SCHEMBL30073105 | 0.78 | SIGMAR1 (0.60) | SIGMAR1TMEM97ADRA2AADRA2BADRA2C | |
| SCHEMBL7982882 | 0.78 | SIGMAR1 (0.53) | SIGMAR1 | |
| SCHEMBL9314619 | 0.78 | SIGMAR1 (0.55) | SIGMAR1TMEM97ADRA2AADRA2BADRA2C | |
| SCHEMBL6672942 | 0.76 | SIGMAR1 (0.62) | SIGMAR1TMEM97ADRA2AADRA2BADRA2C | |
| SCHEMBL3872119 | 0.74 | SIGMAR1 (0.55) | SIGMAR1TMEM97ADRA2AADRA2BADRA2C | |
| SCHEMBL4224135 | 0.74 | SIGMAR1 (0.55) | SIGMAR1TMEM97ADRA2AADRA2BADRA2C | |
| SCHEMBL3692387 | 0.74 | ESR1 (0.58) | SIGMAR1TMEM97ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5807875-A | OBESITY THERAPY | DR. KARL THOMAE GMBH (DE) | 1998-09-15 | — | — | US | disclosed |