Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.53 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984485 | 0.85 | NAMPT (0.60) | SIGMAR1LTA4HHRH3POLBGRIN2B | |
| SCHEMBL7041746 | 0.81 | SIGMAR1 (0.54) | SIGMAR1POLB | |
| SCHEMBL10382817 | 0.78 | SIGMAR1 (0.58) | SIGMAR1LTA4HPOLBGRIN2B | |
| SCHEMBL7981844 | 0.78 | ADRA1D (0.55) | — | |
| Lithium Ion SCHEMBL8530253 | 0.78 | SIGMAR1 (0.50) | SIGMAR1 | |
| SCHEMBL7982875 | 0.77 | SIGMAR1 (0.49) | SIGMAR1LTA4HHRH3POLBGRIN2B | |
| SCHEMBL7985762 | 0.77 | OPRM1 (0.43) | SIGMAR1LTA4HHRH3NAMPT | |
| SCHEMBL10383389 | 0.75 | SIGMAR1 (0.63) | SIGMAR1 | |
| SCHEMBL27746973 | 0.75 | SIGMAR1 (0.74) | SIGMAR1 | |
| SCHEMBL16978068 | 0.74 | DRD2 (0.56) | SIGMAR1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |