Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 4/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8529758 | 0.83 | PDPK1 (0.52) | PDPK1CHEK1RETPSEN1PSEN2 | |
| SCHEMBL7131127 | 0.83 | NTRK1 (0.47) | CHEK1RETTDP1MEN1KMT2A | |
| SCHEMBL8508649 | 0.83 | RPS6KA3 (0.54) | PDPK1CHEK1RETTDP1MEN1 | |
| SCHEMBL5728227 | 0.82 | CHEK1 (0.60) | CHEK1TLK2RETTDP1MEN1 | |
| SCHEMBL5728224 | 0.82 | CHEK1 (0.60) | CHEK1TLK2RETTDP1MEN1 | |
| SCHEMBL15503691 | 0.82 | CHEK1 (0.60) | CHEK1TLK2RETTDP1MEN1 | |
| SCHEMBL8528501 | 0.80 | CHEK1 (0.43) | PDPK1CHEK1RETTDP1MEN1 | |
| SCHEMBL8530158 | 0.80 | RET (0.45) | PDPK1CHEK1RETTDP1MEN1 | |
| SCHEMBL8530156 | 0.80 | PDPK1 (0.55) | PDPK1CHEK1RETTDP1MEN1 | |
| SCHEMBL8301615 | 0.80 | TLK2 (0.58) | PDPK1TLK2MEN1KMT2AKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840745-A | INHIBITING CELL PROLIFERATION, TUMOR GROWTH, METASTASIS, DEVELOPMENT OF ATHEROMATOUS PLAQUE AND RESTENOSIS, CONTROLLING ANGIOGENESIS, TREATING DIABETES, ENHANCING CANCER THERAPY | PHARMACIA S. P. A. (IT) | 1998-11-24 | — | — | US | disclosed |