SCHEMBL8530447

SCHEMBL8530447

CO/C(=N\O)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.48
GAA P10253 5/20 0.44
RAB9A P51151 2/20 0.40
HPGD P15428 3/20 0.39
ALDH1A1 P00352 2/20 0.39
SRC P12931 1/20 0.39
GFER P55789 1/20 0.39
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39
CYP2C19 P33261 1/20 0.39
MAPT P10636 3/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
CASP3 P42574 1/20 0.38
SENP8 Q96LD8 1/20 0.38
SENP7 Q9BQF6 1/20 0.38
SENP6 Q9GZR1 1/20 0.38
HTT P42858 2/20 0.38
CES2 O00748 1/20 0.38
CES1 P23141 1/20 0.38
LMNA P02545 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8530450 1.00 TSHR (0.48) TSHRGAARAB9AHPGDALDH1A1
SCHEMBL27532146 0.88 TSHR (0.39) TSHRGAARAB9AHPGDALDH1A1
SCHEMBL10268873 0.81 TSHR (0.48) TSHRGAARAB9AHPGDALDH1A1
SCHEMBL26741951 0.81 TSHR (0.48) TSHRGAARAB9AHPGDALDH1A1
SCHEMBL674618 0.80 GAA (0.41) TSHRGAAHPGDALDH1A1GFER
SCHEMBL10362382 0.79 CA1 (0.50) TSHRGAAHPGDALDH1A1GFER
SCHEMBL12151890 0.79 TSHR (0.46) TSHRGAARAB9AHPGDALDH1A1
SCHEMBL13962578 0.79 TSHR (0.46) TSHRGAARAB9AALDH1A1SRC
SCHEMBL27812844 0.79 TSHR (0.46) TSHRGAARAB9AHPGDALDH1A1
SCHEMBL14122944 0.79 TSHR (0.46) TSHRGAARAB9AHPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5763640-A OXIMINOMETHYLPHENYL DERIVATIVES ZENECA LIMITED (GB) 1998-06-09 US disclosed
EP-0370629-B2 Fungicides ZENECA LTD (GB) 1998-01-07 EP disclosed
US-5631253-A FUNGICIDES, INSECTICIDES AND MITICIDES USING METHYLOXIME PHENYLPROPENOIC ACID ZENECA LIMITED (GB) 1997-05-20 US disclosed
US-5432197-A Insecticidal, miticidal ZENECA LIMITED (GB) 1995-07-11 US disclosed
US-5371084-A Insecticides and miticides ZENECA LIMITED (GB) 1994-12-06 US disclosed
CN-1024005-C Fungicidal agents ICI PLC (GB) 1994-03-16 CN disclosed
EP-0506149-A2 Fungicides ZENECA LIMITED (GB) 1992-09-30 EP disclosed
US-5055471-A FUNGICIDES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1991-10-08 US disclosed
CN-1042900-A Mycocide ICI PLC (GB) 1990-06-13 CN disclosed
EP-0370629-A1 Fungicides ZENECA LIMITED (GB) 1990-05-30 EP disclosed