Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.79 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | SNCA | P37840 | 3/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29871648 | 0.89 | GPR84 (0.87) | GPR84NPC1CDK2MEN1KMT2A | |
| SCHEMBL24100148 | 0.88 | GPR84 (1.00) | GPR84NPC1CDK2MEN1KMT2A | |
| SCHEMBL31744889 | 0.88 | GPR84 (0.68) | GPR84NPC1MEN1KMT2ASNCA | |
| SCHEMBL31744725 | 0.87 | GPR84 (0.67) | GPR84KMT2ASNCANR4A2ACHE | |
| SCHEMBL2884867 | 0.84 | GPR84 (0.74) | GPR84NPC1CDK2MEN1KMT2A | |
| SCHEMBL22554662 | 0.84 | GPR84 (0.73) | GPR84NPC1CDK2MEN1KMT2A | |
| SCHEMBL8530246 | 0.83 | GPR84 (0.65) | GPR84CDK2MEN1KMT2ASNCA | |
| SCHEMBL2161423 | 0.82 | GPR84 (0.76) | GPR84NPC1CDK2MEN1KMT2A | |
| SCHEMBL2161735 | 0.81 | GPR84 (0.70) | GPR84NPC1CDK2MEN1KMT2A | |
| SCHEMBL8528458 | 0.81 | GPR84 (0.73) | GPR84NPC1MEN1KMT2ASNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0489547-B1 | A process for the preparation of a 3-alkylated indole, intermediates, and a process for the preparation of a derivative thereof | ZENECA LTD (GB) | 1998-07-29 | — | — | EP | disclosed |
| US-5280125-A | Chemical process for the preparation of 3-alkylated indole | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-01-18 | — | — | US | disclosed |
| EP-0489547-A1 | A process for the preparation of a 3-alkylated indole, intermediates, and a process for the preparation of a derivative thereof | ZENECA LIMITED (GB) | 1992-06-10 | — | — | EP | disclosed |