Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.65 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | CPT1A | P50416 | 1/20 | 0.46 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.46 |
| ▸ | SNCA | P37840 | 2/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8425280 | 0.94 | GPR84 (0.56) | GPR84CYSLTR2CYSLTR1IDO1RXFP1 | |
| SCHEMBL8528458 | 0.89 | GPR84 (0.73) | GPR84CYSLTR2CYSLTR1IDO1CPT1A | |
| SCHEMBL8427130 | 0.87 | GPR84 (0.67) | GPR84CYSLTR2CYSLTR1IDO1CPT1A | |
| SCHEMBL29251314 | 0.84 | GPR84 (0.78) | GPR84RXFP1CYP3A4MAPTCDK2 | |
| SCHEMBL8427078 | 0.84 | GPR84 (0.46) | GPR84CYSLTR2CYSLTR1SNCACYP3A4 | |
| SCHEMBL27273115 | 0.83 | GPR84 (0.63) | GPR84CYSLTR2CYSLTR1IDO1CPT1A | |
| SCHEMBL8530662 | 0.83 | GPR84 (0.79) | GPR84SNCACDK2MEN1KMT2A | |
| SCHEMBL8427079 | 0.83 | GPR84 (0.44) | GPR84CYSLTR2CYSLTR1IDO1RXFP1 | |
| SCHEMBL8951231 | 0.81 | GPR84 (0.63) | GPR84CYSLTR2CYSLTR1IDO1CPT1A | |
| SCHEMBL8536304 | 0.81 | GPR84 (0.47) | GPR84RXFP1TACR1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0489547-B1 | A process for the preparation of a 3-alkylated indole, intermediates, and a process for the preparation of a derivative thereof | ZENECA LTD (GB) | 1998-07-29 | — | — | EP | disclosed |
| EP-0432984-B1 | Carbamoyl derivatives | ZENECA LTD (GB) | 1998-03-04 | — | — | EP | disclosed |
| CN-1025786-C | Carbamoyl derivatives | ICI PLC (GB) | 1994-08-31 | — | — | CN | disclosed |
| US-5334765-A | Intermediate for leukotriene antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-08-02 | — | — | US | disclosed |
| US-5286740-A | Leukotrine antagonists; antiinflammatory agnets, antiallergens, treating asthma | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-02-15 | — | — | US | disclosed |
| US-5280125-A | Chemical process for the preparation of 3-alkylated indole | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-01-18 | — | — | US | disclosed |
| EP-0489547-A1 | A process for the preparation of a 3-alkylated indole, intermediates, and a process for the preparation of a derivative thereof | ZENECA LIMITED (GB) | 1992-06-10 | — | — | EP | disclosed |
| CN-1053604-A | CARBAMOYL DERIVATIVES | ICI PLC (GB) | 1991-08-07 | — | — | CN | disclosed |
| EP-0432984-A2 | Carbamoyl derivatives | ZENECA LIMITED (GB) | 1991-06-19 | — | — | EP | disclosed |