Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | CA12 | O43570 | 5/20 | 0.53 |
| ▸ | CA1 | P00915 | 5/20 | 0.53 |
| ▸ | CA2 | P00918 | 5/20 | 0.53 |
| ▸ | CA9 | Q16790 | 5/20 | 0.53 |
| ▸ | TYMP | P19971 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL920293 | 0.85 | LMNA (0.60) | LMNATHRBCYP2C19KMT2ACA12 | |
| SCHEMBL11390072 | 0.84 | CA12 (0.64) | LMNATHRBCYP2C19KMT2ACA12 | |
| SCHEMBL12391050 | 0.82 | LMNA (0.57) | LMNATHRBCYP2C19KMT2ACA12 | |
| SCHEMBL13897245 | 0.81 | LMNA (0.63) | LMNATHRBCYP2C19KMT2ACA12 | |
| SCHEMBL21327770 | 0.81 | LMNA (0.52) | LMNATHRBCYP2C19KMT2ACA12 | |
| SCHEMBL2293445 | 0.81 | CYP2C19 (0.56) | LMNATHRBCYP2C19KMT2ACA12 | |
| SCHEMBL28639392 | 0.81 | LMNA (0.52) | LMNATHRBCYP2C19KMT2ACA12 | |
| SCHEMBL9272320 | 0.81 | KMT2A (0.54) | LMNATHRBCYP2C19KMT2ACA12 | |
| SCHEMBL29579255 | 0.81 | CA12 (0.53) | LMNATHRBCYP2C19KMT2ACA12 | |
| SCHEMBL16752479 | 0.81 | CA12 (0.53) | LMNATHRBCYP2C19KMT2ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780653-A | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers | VIVORX PHARMACEUTICALS, INC. (US) | 1998-07-14 | — | — | US | disclosed |
| WO-1996040091-A1 | DUAL FUNCTIONAL CYTOTOXIC/RADIOSENSITIZER COMPOUNDS AND METHODS FOR THE PREPARATION THEREOF | VIVORX PHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |