Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 5/20 | 0.48 |
| ▸ | CA1 | P00915 | 5/20 | 0.48 |
| ▸ | CA2 | P00918 | 5/20 | 0.48 |
| ▸ | CA9 | Q16790 | 5/20 | 0.48 |
| ▸ | TYMP | P19971 | 3/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15325016 | 0.85 | LMNA (0.61) | CYP2C19LMNATHRBCYP2D6KMT2A | |
| SCHEMBL11109803 | 0.84 | LMNA (0.56) | CYP2C19LMNATHRBCYP2D6KMT2A | |
| SCHEMBL8530813 | 0.81 | LMNA (0.59) | CYP2C19LMNATHRBCYP2D6KMT2A | |
| SCHEMBL3914305 | 0.80 | LMNA (0.62) | CYP2C19LMNATHRBCYP2D6KMT2A | |
| SCHEMBL11879496 | 0.79 | LMNA (0.61) | CYP2C19LMNATHRBCYP2D6KMT2A | |
| SCHEMBL4319784 | 0.79 | LMNA (0.61) | CYP2C19LMNATHRBCYP2D6KMT2A | |
| SCHEMBL13657445 | 0.78 | LMNA (0.57) | CYP2C19LMNATHRBCYP2D6KMT2A | |
| SCHEMBL3835016 | 0.78 | LMNA (0.60) | CYP2C19LMNATHRBCYP2D6KMT2A | |
| SCHEMBL9272320 | 0.78 | KMT2A (0.54) | CYP2C19LMNATHRBCYP2D6KMT2A | |
| SCHEMBL17831274 | 0.77 | LMNA (0.56) | CYP2C19LMNATHRBCYP2D6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309554-B2 | Hypoxia activated drugs of nitrogen mustard alkylators | THRESHOLD PHARMACEUTICALS (US) | 2012-11-13 | — | — | US | disclosed |
| US-20110190310-A1 | Hypoxia Activated Drugs Of Nitrogen Mustard Alkylators | THRESHOLD PHARMACEUTICALS, INC. | 2011-08-04 | — | — | US | disclosed |
| WO-2009140553-A2 | HYPOXIA ACTIVATED DRUGS OF NITROGEN MUSTARD ALKYLATORS | THRESHOLD PHARMACEUTICALS, INC. (US) | 2009-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190310-A1 | Hypoxia Activated Drugs Of Nitrogen Mustard Alkylators | HIF1AN, HIF1A, HYOU1 | CYP2C19 1207/4885LMNA 3450/4885THRB 2298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.