Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | CTSG | P08311 | 1/20 | 0.41 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | FASN | P49327 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7417047 | 0.82 | GLA (0.66) | GLANPSR1ELANECTSGPRTN3 | |
| SCHEMBL16174918 | 0.78 | GLA (0.49) | GLANPSR1ELANECTSGPRTN3 | |
| SCHEMBL16174944 | 0.76 | GLA (0.46) | GLANPSR1ELANEEP300CTRB1 | |
| SCHEMBL2976090 | 0.76 | EP300 (0.46) | ELANEEP300CES2TSHRHTT | |
| SCHEMBL11594580 | 0.71 | TSHR (0.54) | GLANPSR1EP300CTRB1CES2 | |
| SCHEMBL16174891 | 0.71 | GLA (0.45) | GLANPSR1EP300CTRB1TSHR | |
| SCHEMBL3103917 | 0.70 | GLA (0.66) | GLANPSR1 | |
| SCHEMBL3093178 | 0.70 | GLA (0.58) | GLANPSR1HTT | |
| SCHEMBL20878240 | 0.69 | CTRB1 (0.46) | EP300CTRB1CES2TSHRHTT | |
| SCHEMBL3524746 | 0.69 | GLA (0.43) | GLANPSR1ELANECTSGPRTN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623606-B1 | Peptidic ketones as interleukin-1beta-converting enzyme inhibitors | SANOFI SA (FR) | 1998-01-07 | — | — | EP | disclosed |
| US-5585486-A | Peptidic ketones as interleukin-1β-converting enzyme inhibitors | STERLING WINTHROP INC. (US) | 1996-12-17 | — | — | US | disclosed |
| US-5462939-A | Peptidic ketones as interleukin-1β-converting enzyme inhibitors | STERLING WINTHROP INC. (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0623606-A2 | Peptidic ketones as interleukin-1beta-converting enzyme inhibitors | STERLING WINTHROP INC. (US) | 1994-11-09 | — | — | EP | disclosed |