Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | USP2 | O75604 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CLK1 | P49759 | 1/20 | 0.55 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11266059 | 0.85 | SLC27A1 (0.60) | SMN1; SMN2ALDH1A1POLBKMT2AHTT | |
| SCHEMBL8354249 | 0.84 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNAUSP2TSHRLRRK2 | |
| SCHEMBL8354375 | 0.82 | SMN1; SMN2 (0.68) | SMN1; SMN2LMNAUSP2TSHRLRRK2 | |
| Hydrochloric Acid SCHEMBL8353865 | 0.82 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAUSP2TSHRLRRK2 | |
| SCHEMBL8354234 | 0.81 | ALDH1A1 (0.76) | SMN1; SMN2LMNAUSP2TSHRALDH1A1 | |
| SCHEMBL21753691 | 0.80 | LRRK2 (1.00) | SMN1; SMN2LMNAUSP2LRRK2ALDH1A1 | |
| SCHEMBL30620435 | 0.79 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAUSP2TSHRALDH1A1 | |
| SCHEMBL27008579 | 0.79 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAUSP2TSHRALDH1A1 | |
| SCHEMBL8350371 | 0.79 | SLC27A1 (0.68) | LMNAALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL8356375 | 0.79 | ALDH1A1 (0.75) | SMN1; SMN2LMNAUSP2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |