Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CLK1 | P49759 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL402967 | 0.85 | PAX8 (0.54) | PAX8GAAMEN1SLC2A1KMT2A | |
| SCHEMBL3659497 | 0.85 | PAX8 (0.58) | PAX8GAAMEN1SLC2A1KMT2A | |
| SCHEMBL403648 | 0.84 | PAX8 (0.68) | PAX8GAAMEN1SLC2A1KMT2A | |
| Hydrochloric Acid SCHEMBL15093957 | 0.83 | PAX8 (0.70) | PAX8GAAMEN1SLC2A1KMT2A | |
| SCHEMBL3657702 | 0.83 | PAX8 (0.57) | PAX8GAAMEN1SLC2A1KMT2A | |
| SCHEMBL402202 | 0.81 | PAX8 (0.55) | PAX8GAAMEN1SLC2A1KMT2A | |
| SCHEMBL401911 | 0.81 | TBXAS1 (0.52) | PAX8GAAMEN1SLC2A1KMT2A | |
| SCHEMBL401857 | 0.80 | PAX8 (0.56) | PAX8GAAMEN1SLC2A1KMT2A | |
| SCHEMBL402964 | 0.79 | PAX8 (0.53) | PAX8GAAMEN1SLC2A1KMT2A | |
| SCHEMBL402958 | 0.79 | GAA (0.60) | GAAMEN1SLC2A1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432764-A1 | SUBSTITUTED QUINOLINES FOR USE AS VEGF INHIBITORS | ClanoTech AB (SE) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010133669-A1 | SUBSTITUTED QUINOLINES FOR USE AS VEGF INHIBITORS | CLANOTECH AB (SE) | 2010-11-25 | — | — | WO | disclosed |