Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15253433 | 0.96 | HRH3 (0.47) | HRH3GPR119 | |
| SCHEMBL15253067 | 0.92 | GPR119 (0.44) | HRH3GPR119F2F10PRSS1 | |
| SCHEMBL8531975 | 0.90 | GPR119 (0.53) | HRH3GPR119 | |
| SCHEMBL8618221 | 0.90 | GPR119 (0.47) | HRH3GPR119 | |
| SCHEMBL8535353 | 0.90 | MAPT (0.47) | HRH3GPR119F2F10PRSS1 | |
| SCHEMBL15253425 | 0.88 | MAPT (0.43) | HRH3GPR119F2F10PRSS1 | |
| SCHEMBL15253312 | 0.88 | MAPT (0.43) | HRH3GPR119F2F10PRSS1 | |
| SCHEMBL8515563 | 0.88 | F10 (0.41) | HRH3GPR119F2F10PRSS1 | |
| SCHEMBL15253289 | 0.88 | GPR119 (0.44) | HRH3GPR119F2F10PRSS1 | |
| SCHEMBL15253389 | 0.88 | GPR119 (0.40) | HRH3GPR119F2F10PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9000175-B2 | Bicyclic GPR119 modulators | LUPIN LIMITED (IN) | 2015-04-07 | — | — | US | claimed |
| EP-2643311-A1 | BICYCLIC GPR119 MODULATORS | Lupin Limited (IN) | 2013-10-02 | — | — | EP | claimed |
| US-20130245000-A1 | BICYCLIC GPR119 MODULATORS | LUPIN LIMITED (IN) | 2013-09-19 | — | — | US | claimed |
| WO-2012069917-A1 | BICYCLIC GPR119 MODULATORS | LUPIN LIMITED (IN) | 2012-05-31 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130245000-A1 | BICYCLIC GPR119 MODULATORS | GPR119, GPR180, GPBAR1 | HRH3 479/4885GPR119 1/4885F2 3907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.