Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.37 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8537358 | 0.95 | ROCK1 (0.41) | ROCK1MAPTL3MBTL1KMT2APOLB | |
| SCHEMBL15253243 | 0.90 | GPR119 (0.42) | ROCK1MAPTL3MBTL1KMT2APOLB | |
| SCHEMBL15253109 | 0.89 | CHEK2 (0.42) | MAPTL3MBTL1GPR119 | |
| SCHEMBL8535909 | 0.89 | GPR119 (0.52) | MAPTL3MBTL1KMT2ARAB9AGPR119 | |
| SCHEMBL9262615 | 0.88 | KDM1A (0.42) | ROCK1MAPTCHRNA7PLK1PLK3 | |
| SCHEMBL15253108 | 0.87 | ROCK1 (0.38) | ROCK1MAPTL3MBTL1RAB9ANPC1 | |
| SCHEMBL8530737 | 0.86 | PIK3CD (0.41) | L3MBTL1CHRNA7GPR119 | |
| SCHEMBL8533100 | 0.86 | CSF1R (0.40) | ROCK1L3MBTL1POLBRAB9ANPC1 | |
| SCHEMBL9256413 | 0.85 | GPR119 (0.44) | ROCK1MAPTRAB9ANPC1GPR119 | |
| SCHEMBL8530780 | 0.83 | GPR119 (0.41) | KMT2APOLBNPC1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643311-A1 | BICYCLIC GPR119 MODULATORS | Lupin Limited (IN) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012069917-A1 | BICYCLIC GPR119 MODULATORS | LUPIN LIMITED (IN) | 2012-05-31 | — | — | WO | disclosed |