Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 12/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15253109 | 0.95 | CHEK2 (0.42) | CHEK2GPR119L3MBTL1 | |
| SCHEMBL8537358 | 0.89 | ROCK1 (0.41) | CHRNA7L3MBTL1 | |
| SCHEMBL15253286 | 0.88 | GPR119 (0.49) | PIK3CDCHEK2GPR119L3MBTL1 | |
| SCHEMBL15253243 | 0.86 | GPR119 (0.42) | GPR119CHRNA7L3MBTL1 | |
| SCHEMBL8533555 | 0.86 | ROCK1 (0.42) | GPR119CHRNA7L3MBTL1 | |
| SCHEMBL8535761 | 0.86 | PIK3CD (0.43) | PIK3CDCHEK2GPR119L3MBTL1 | |
| SCHEMBL9258674 | 0.86 | HPGDS (0.45) | CHEK2GPR119USP30 | |
| SCHEMBL15253238 | 0.85 | CHEK2 (0.44) | CHEK2GPR119 | |
| SCHEMBL8535909 | 0.85 | GPR119 (0.52) | GPR119L3MBTL1 | |
| SCHEMBL8537789 | 0.84 | CHEK2 (0.43) | CHEK2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9000175-B2 | Bicyclic GPR119 modulators | LUPIN LIMITED (IN) | 2015-04-07 | — | — | US | disclosed |
| EP-2643311-A1 | BICYCLIC GPR119 MODULATORS | Lupin Limited (IN) | 2013-10-02 | — | — | EP | disclosed |
| US-20130245000-A1 | BICYCLIC GPR119 MODULATORS | LUPIN LIMITED (IN) | 2013-09-19 | — | — | US | disclosed |
| WO-2012069917-A1 | BICYCLIC GPR119 MODULATORS | LUPIN LIMITED (IN) | 2012-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130245000-A1 | BICYCLIC GPR119 MODULATORS | GPR119, GPR180, GPBAR1 | PIK3CD 2657/4885CHEK2 3915/4885GPR119 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.