Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8535984 | 0.84 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL6440411 | 0.84 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL8560198 | 0.83 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2L3MBTL1GAA | |
| SCHEMBL8566008 | 0.83 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2L3MBTL1GAA | |
| SCHEMBL7424161 | 0.83 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2L3MBTL1GAA | |
| SCHEMBL13208710 | 0.81 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL22174730 | 0.80 | HTR2C (0.49) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL28743011 | 0.79 | ALDH1A1 (0.48) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL29235094 | 0.79 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2L3MBTL1GAA | |
| SCHEMBL13208713 | 0.78 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885869-A1 | THERAPEUTIC AGENT FOR DIABETES | Japan Tobacco Inc. (JP) | 1998-12-23 | — | — | EP | disclosed |