Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6440411 | 1.00 | NPC1 (0.50) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL6438945 | 0.89 | NPC1 (0.46) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL8533641 | 0.84 | NPC1 (0.57) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL22174730 | 0.84 | HTR2C (0.49) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL23626287 | 0.82 | NPC1 (0.47) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL7423807 | 0.82 | NPC1 (0.64) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL7423800 | 0.82 | NPC1 (0.64) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL13208710 | 0.82 | NPC1 (0.47) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL13208713 | 0.82 | NPC1 (0.44) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL28743011 | 0.80 | ALDH1A1 (0.48) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474243-B1 | 1-Methylcarbapenem derivatives and process for preparation thereof | TANABE SEIYAKU CO (JP) | 1998-04-01 | — | — | EP | disclosed |
| CN-1033455-C | 1-methylcarbapenem derivatives and process for preparation thereof | TANABE SEIYAKU CO (JP) | 1996-12-04 | — | — | CN | disclosed |
| US-5208348-A | Intermediates for thienamycin derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1993-05-04 | — | — | US | disclosed |
| US-5153187-A | Microbiocides having stability against dehydropeptidase and high absorrbability by oral administration | TANABE SEIYAKU CO., LTD. (JP) | 1992-10-06 | — | — | US | disclosed |
| CN-1060093-A | 1-methylcarbapenem derivatives and preparation method thereof | TANABE SEIYAKU CO (JP) | 1992-04-08 | — | — | CN | disclosed |
| EP-0474243-A1 | 1-Methylcarbapenem derivatives and process for preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1992-03-11 | — | — | EP | disclosed |