Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methamphetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.72 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.72 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.72 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levmetamfetamine SCHEMBL29878484 | 1.00 | TAAR1 (0.72) | TAAR1SIGMAR1SLC18A2NPC1RAB9A | |
| Mucic Acid SCHEMBL6466756 | 0.93 | TAAR1 (0.68) | TAAR1SIGMAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL7036430 | 0.87 | SIGMAR1 (0.81) | TAAR1SIGMAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL7036433 | 0.87 | SIGMAR1 (0.81) | TAAR1SIGMAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL29112697 | 0.87 | SIGMAR1 (0.81) | TAAR1SIGMAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL27438559 | 0.87 | SIGMAR1 (0.95) | TAAR1SIGMAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL28233460 | 0.86 | SIGMAR1 (0.78) | TAAR1SIGMAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL20490091 | 0.85 | SIGMAR1 (0.84) | TAAR1SIGMAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL18227057 | 0.85 | SIGMAR1 (0.91) | TAAR1SIGMAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL20211416 | 0.85 | SIGMAR1 (1.00) | TAAR1SIGMAR1SLC18A2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110642721-B | Preparation method of selegiline hydrochloride | 安徽贝克生物制药有限公司 | 2022-09-30 | — | — | CN | disclosed |
| CN-110642721-A | Preparation method of selegiline hydrochloride | 安徽贝克生物制药有限公司 | 2020-01-03 | — | — | CN | disclosed |
| EP-0713858-B1 | Improved process for the preparation of propargyl ammonium-chloride derivatives | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1998-07-29 | — | — | EP | disclosed |
| EP-0713858-A1 | Improved process for the preparation of propargyl ammonium-chloride derivatives | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1996-05-29 | — | — | EP | disclosed |
| US-5449828-A | Process for the preparation of propargyl ammonium-chloride | CHINOIN GYOGYSZER- ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1995-09-12 | — | — | US | disclosed |