Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 13/20 | 0.54 |
| ▸ | LTA4H | P09960 | 6/20 | 0.50 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL861355 | 0.96 | TLR7 (0.56) | TLR7LTA4H | |
| SCHEMBL861830 | 0.90 | TLR7 (0.60) | TLR7 | |
| SCHEMBL853780 | 0.89 | DHFR (0.58) | TLR7LTA4H | |
| SCHEMBL861371 | 0.89 | DHFR (0.57) | TLR7LTA4H | |
| SCHEMBL855086 | 0.85 | DHFR (0.47) | TLR7 | |
| SCHEMBL3709605 | 0.85 | TLR7 (0.73) | TLR7 | |
| SCHEMBL3699429 | 0.84 | TLR7 (0.72) | TLR7 | |
| SCHEMBL853213 | 0.83 | TLR7 (0.57) | TLR7 | |
| SCHEMBL854804 | 0.83 | TLR7 (0.55) | TLR7LTA4H | |
| SCHEMBL3702171 | 0.81 | TLR7 (0.75) | TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432768-A1 | NOVEL PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AND FURTHER DISEASES | AstraZeneca AB (SE) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010133885-A1 | NOVEL PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AND FURTHER DISEASES | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | WO | disclosed |