Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 16/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL853436 | 0.96 | TLR7 (0.54) | TLR7LTA4H | |
| SCHEMBL861830 | 0.94 | TLR7 (0.60) | TLR7HRH3TLR8 | |
| SCHEMBL853780 | 0.86 | DHFR (0.58) | TLR7LTA4H | |
| SCHEMBL855086 | 0.85 | DHFR (0.47) | TLR7TLR8 | |
| SCHEMBL3702171 | 0.85 | TLR7 (0.75) | TLR7TLR8 | |
| SCHEMBL861371 | 0.85 | DHFR (0.57) | TLR7LTA4H | |
| SCHEMBL853213 | 0.83 | TLR7 (0.57) | TLR7TLR8 | |
| SCHEMBL854804 | 0.83 | TLR7 (0.55) | TLR7LTA4HTLR8 | |
| SCHEMBL3709605 | 0.81 | TLR7 (0.73) | TLR7TLR8 | |
| SCHEMBL854178 | 0.81 | ALDH1A1 (0.51) | TLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432768-A1 | NOVEL PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AND FURTHER DISEASES | AstraZeneca AB (SE) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010133885-A1 | NOVEL PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AND FURTHER DISEASES | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | WO | disclosed |