Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 2/20 | 0.55 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.55 |
| ▸ | HTR3B | O95264 | 2/20 | 0.55 |
| ▸ | HTR3A | P46098 | 2/20 | 0.55 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.55 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29128401 | 0.86 | ADRB1 (0.59) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL30646968 | 0.86 | ADRB1 (0.59) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL29128404 | 0.86 | ADRB1 (0.59) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL1255943 | 0.83 | ADRB1 (0.51) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4240000 | 0.82 | HTR3E (0.61) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL12892626 | 0.82 | HTR3E (0.61) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL2245201 | 0.82 | HTR3E (0.61) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL30208090 | 0.82 | HTR3E (0.61) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4252272 | 0.82 | ADRB1 (0.58) | ADRB1HTR2CALDH1A1 | |
| SCHEMBL4252269 | 0.82 | ADRB1 (0.58) | ADRB1HTR2CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110345250-A | A kind of high-temperature and high-presure resistent metallic cover flat shim and preparation method thereof | 慈溪埃弗龙密封件有限公司 | 2019-10-18 | — | — | CN | claimed |
| CN-110345250-A | A kind of high-temperature and high-presure resistent metallic cover flat shim and preparation method thereof | 慈溪埃弗龙密封件有限公司 | 2019-10-18 | — | — | CN | disclosed |
| US-5739334-A | CHEMICAL INTERMEDIATES FOR NEW ANTIDEPRESSANT WITH SIDE EFFECT REDUCTION | ISTITUTO RICERCA FRANCESCO ANGELINI S.P.A. (IT) | 1998-04-14 | — | — | US | disclosed |
| US-5726178-A | Alkyl derivatives of trazodone with CNS activity | ISTITUTO RICERCA FRANCESCO ANGELINI S.P.A. (IT) | 1998-03-10 | — | — | US | disclosed |
| US-5543563-A | ANTIDEPRESSANTS; SIDE EFFECT REDUCTION | ISTITUTO RICERCA FRANCESCO ANGELINI S.P.A. (IT) | 1996-08-06 | — | — | US | disclosed |
| EP-0623131-B1 | ALKYL DERIVATIVES OF TRAZODONE WITH CNS ACTIVITY | ANGELINI RICERCHE SPA (IT) | 1996-04-03 | — | — | EP | disclosed |
| EP-0623131-A1 | ALKYL DERIVATIVES OF TRAZODONE WITH CNS ACTIVITY. | ANGELINI FRANCESCO IST RICERCA (IT) | 1994-11-09 | — | — | EP | disclosed |
| WO-1993014091-A1 | ALKYL DERIVATIVES OF TRAZODONE WITH CNS ACTIVITY | ISTITUTO RICERCA FRANCESCO ANGELINI S.P.A. (IT) | 1993-07-22 | — | — | WO | disclosed |