Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.69 |
| ▸ | ITGAV | P06756 | 20/20 | 0.69 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6360649 | 0.88 | ITGB3 (0.83) | ITGB3ITGAVITGB5 | |
| SCHEMBL2491273 | 0.82 | ITGB3 (1.00) | ITGB3ITGAVITGB5 | |
| SCHEMBL2493736 | 0.79 | ITGB3 (0.70) | ITGB3ITGAVITGB5 | |
| SCHEMBL2488336 | 0.78 | ITGB3 (1.00) | ITGB3ITGAVITGB5 | |
| SCHEMBL2490009 | 0.77 | ITGB3 (1.00) | ITGB3ITGAVITGB5 | |
| SCHEMBL861284 | 0.77 | ITGB3 (0.85) | ITGB3ITGAVITGB5 | |
| SCHEMBL12209661 | 0.77 | ITGB3 (0.90) | ITGB3ITGAVITGB5 | |
| SCHEMBL861178 | 0.76 | ITGB3 (1.00) | ITGB3ITGAVITGB5 | |
| SCHEMBL854741 | 0.76 | ITGB3 (0.65) | ITGB3ITGAVITGB5 | |
| SCHEMBL2490010 | 0.76 | ITGB3 (1.00) | ITGB3ITGAVITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425010-B8 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | JANSSEN PHARMACEUTICALS INC (US) | 2012-03-28 | — | — | EP | claimed |
| EP-1425010-A4 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | ORTHO MCNEIL PHARM INC (US) | 2009-07-29 | — | — | EP | claimed |
| EP-1425010-A1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2004-06-09 | — | — | EP | claimed |
| WO-2002060438-A1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2002-08-08 | — | — | WO | claimed |