SCHEMBL8534729

SCHEMBL8534729

CCS(=O)(=O)c1ccccc1S(=O)(=O)NC(C)(C)C

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NSD2 O96028 2/20 0.49
MAPT P10636 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
KDM4E B2RXH2 1/20 0.44
MEN1 O00255 1/20 0.44
NPC1 O15118 1/20 0.44
LMNA P02545 1/20 0.44
HPGD P15428 1/20 0.44
RAB9A P51151 1/20 0.44
KMT2A Q03164 1/20 0.44
PARG Q86W56 1/20 0.44
PSIP1 O75475 1/20 0.42
ALOX5AP P20292 7/20 0.40
FEN1 P39748 7/20 0.40
ALDH1A1 P00352 3/20 0.40
CA12 O43570 1/20 0.37
CA9 Q16790 1/20 0.37
SIRT2 Q8IXJ6 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2803354 0.88 NSD2 (0.58) NSD2MAPTSMN1; SMN2KDM4EMEN1
SCHEMBL28680071 0.81 PSIP1 (0.59) MAPTSMN1; SMN2LMNAHPGDPSIP1
SCHEMBL13075810 0.80 NSD2 (0.51) NSD2MAPTSMN1; SMN2KDM4EMEN1
SCHEMBL23345388 0.80 NSD2 (0.51) NSD2MAPTSMN1; SMN2KDM4EMEN1
SCHEMBL15882505 0.78 CA1 (0.52) MAPTHPGDPSIP1CA12CA9
SCHEMBL29707981 0.78 CA1 (0.52) MAPTHPGDPSIP1CA12CA9
SCHEMBL8536463 0.78 NSD2 (0.43) NSD2MAPTSMN1; SMN2KDM4EMEN1
SCHEMBL9038749 0.76 COMT (0.43) NSD2MAPTSMN1; SMN2KDM4EMEN1
SCHEMBL8780846 0.76 ALDH1A1 (0.41) NSD2MAPTSMN1; SMN2KDM4EMEN1
SCHEMBL634084 0.76 NSD2 (0.51) NSD2MAPTSMN1; SMN2KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0842154-A1 SUBSTITUTED HYDRAZINOPHENYLSULFONYL UREAS, A PROCESS FOR PREPARING THE SAME AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS Hoechst Schering AgrEvo GmbH (DE) 1998-05-20 EP disclosed
WO-1997000247-A1 SUBSTITUTED HYDRAZINOPHENYLSULFONYL UREAS, A PROCESS FOR PREPARING THE SAME AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS HOECHST SCHERING AGREVO GMBH (DE) 1997-01-03 WO disclosed