Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 11/20 | 0.62 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | P2RY6 | Q15077 | 3/20 | 0.52 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.52 |
| ▸ | NT5E | P21589 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | HBB | P68871 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8534790 | 1.00 | TYMP (0.62) | TYMPHSP90AA1P2RY6P2RY14NT5E | |
| SCHEMBL9229284 | 0.93 | HSP90AA1 (0.60) | TYMPHSP90AA1P2RY6P2RY14NT5E | |
| SCHEMBL9229289 | 0.93 | HSP90AA1 (0.60) | TYMPHSP90AA1P2RY6P2RY14NT5E | |
| SCHEMBL8542375 | 0.92 | HSP90AA1 (0.59) | TYMPHSP90AA1P2RY6P2RY14NT5E | |
| SCHEMBL7805446 | 0.92 | HSP90AA1 (0.59) | TYMPHSP90AA1P2RY6P2RY14NT5E | |
| SCHEMBL3069438 | 0.90 | TYMP (0.62) | TYMPP2RY6P2RY14 | |
| SCHEMBL9710318 | 0.90 | TYMP (0.62) | TYMPP2RY6P2RY14 | |
| SCHEMBL13714472 | 0.90 | TYMP (0.62) | TYMPP2RY6P2RY14 | |
| SCHEMBL13205014 | 0.90 | TYMP (0.62) | TYMPP2RY6P2RY14 | |
| SCHEMBL15974161 | 0.90 | TYMP (0.62) | TYMPP2RY6P2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5741900-A | REACTING PROTECTED FLUOROURIDINE WITH SUCCINIC ANHYDRIDE, ATTACHING TO LONG-CHAIN ALKYLAMINE CONTROLLED PORE GLASS IN ANHYDROUS PYRIDINE IN PRESENCE OF DIMETHYLAMINOPYRIDINE AND DIMETHYLAMINOPROPYL/ETHYLCARBODIIMIDE | THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 1998-04-21 | — | — | US | disclosed |
| US-5663321-A | INHIBITOR OF THYMIDYLATE SYNTHASE; ANTICANCER/ANTITUMOR AGENTS | THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 1997-09-02 | — | — | US | disclosed |
| US-5614505-A | 5-FLUOROURIDINE OR 5-FLUORODEOXYURIDINE, DRUG DELIVERY, IMPROVED BIOAVAILABILITY, ANTICARCINOGENIC AGENTS | THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 1997-03-25 | — | — | US | disclosed |
| US-5457187-A | Antitumor, anticarcinogeic agents | BOARD OF REGENTS UNIVERSITY OF NEBRASKA (US) | 1995-10-10 | — | — | US | disclosed |