Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.50 |
| ▸ | HTR3B | O95264 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | HTR5A | P47898 | 1/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | CASP6 | P55212 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27483128 | 0.86 | HRH3 (0.55) | SIGMAR1KDM4ENSD2LMNAMAPT | |
| SCHEMBL15265439 | 0.83 | AGXT (0.56) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL2270689 | 0.81 | HRH3 (0.61) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8532314 | 0.77 | TSHR (0.56) | SIGMAR1KDM4EMAPTTSHRHTT | |
| SCHEMBL1239752 | 0.77 | MAPT (0.55) | SIGMAR1KDM4ENSD2LMNAMAPT | |
| SCHEMBL593143 | 0.76 | SLC6A4 (0.71) | SIGMAR1HTR3EHTR3BHTR3AHTR5A | |
| SCHEMBL31606107 | 0.76 | TMEM97 (0.40) | SIGMAR1TMEM97ADRA2AADRA2BADRA2C | |
| SCHEMBL15093971 | 0.76 | CYP2A13 (0.49) | SIGMAR1KDM4ELMNASMN1; SMN2TMEM97 | |
| SCHEMBL11585390 | 0.75 | SIGMAR1 (0.56) | SIGMAR1ADRA2CSLC6A4HRH3CXCR4 | |
| SCHEMBL16830448 | 0.75 | SLC6A4 (0.69) | SIGMAR1HTR3AADRA2CSLC6A4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847159-A | 1- ω-(3,4-dihydro-2-naphthalenyl)alkyl!-cyclic amine derivatives, process for preparing the same, and pharmaceutical composition containing the same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1998-12-08 | — | — | US | disclosed |
| EP-0825180-A1 | 1-OMEGA-(3,4-DIHYDRO-2-NAPHTHALENYL)ALKYL] CYCLIC AMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL COMPOSITION CONTAINING THE SAME | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |