Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.62 |
| ▸ | ACHE | P22303 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | CHKA | P35790 | 1/20 | 0.59 |
| ▸ | MC4R | P32245 | 1/20 | 0.57 |
| ▸ | MC5R | P33032 | 1/20 | 0.57 |
| ▸ | HTR3A | P46098 | 2/20 | 0.56 |
| ▸ | CXCR4 | P61073 | 4/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | CCR2 | P41597 | 1/20 | 0.53 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16830448 | 0.98 | SLC6A4 (0.69) | SLC6A4KMT2ASIGMAR1ACHEPKM | |
| SCHEMBL10460248 | 0.95 | SLC6A4 (0.65) | SLC6A4KMT2ASIGMAR1ACHEPKM | |
| SCHEMBL10135595 | 0.94 | SLC6A4 (0.64) | SLC6A4KMT2ASIGMAR1ACHEPKM | |
| SCHEMBL27999347 | 0.87 | KMT2A (0.89) | KMT2AACHEPKMCHKAMC4R | |
| SCHEMBL11585390 | 0.85 | SIGMAR1 (0.56) | SLC6A4KMT2ASIGMAR1CXCR4MEN1 | |
| SCHEMBL31392631 | 0.84 | CHKA (0.79) | KMT2AACHEPKMCHKAMC4R | |
| SCHEMBL31097161 | 0.84 | KMT2A (0.77) | KMT2ASIGMAR1ACHEPKMCHKA | |
| SCHEMBL11586921 | 0.83 | CXCR4 (0.59) | SLC6A4KMT2ASIGMAR1ACHECHKA | |
| SCHEMBL8671948 | 0.83 | SLC6A4 (1.00) | SLC6A4KMT2ASIGMAR1PKMMC4R | |
| SCHEMBL4750742 | 0.82 | KMT2A (1.00) | KMT2ASIGMAR1ACHEPKMCHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873320-B1 | PIPERAZINE DERIVATIVES AS TACHYKININ ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-12 | — | — | EP | claimed |
| EP-3796900-B1 | TRITERPENE AMINE DERIVATIVES | DFH THERAPEUTICS (US) | 2026-04-08 | — | — | EP | disclosed |
| US-11236122-B2 | Triterpene amine derivatives | DFH THERAPEUTICS (US) | 2022-02-01 | — | — | US | disclosed |
| US-20210253627-A1 | TRITERPENE AMINE DERIVATIVES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2021-08-19 | — | — | US | disclosed |
| EP-3796900-A1 | TRITERPENE AMINE DERIVATIVES | DFH Therapeutics (US) | 2021-03-31 | — | — | EP | disclosed |
| US-20180360824-A1 | PROCASPASE-ACTIVATING COMPOUNDS AND METHODS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2018-12-20 | — | — | US | disclosed |
| US-10093630-B2 | Pyrazole compounds and methods of making and using same | ABIDE THERAPEUTICS, INC. (US) | 2018-10-09 | — | — | US | disclosed |
| US-10022371-B2 | Procaspase-activating compounds and methods | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2018-07-17 | — | — | US | disclosed |
| US-10022371-B2 | Procaspase-activating compounds and methods | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2018-07-17 | — | — | US | disclosed |
| US-10022371-B2 | Procaspase-activating compounds and methods | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2018-07-17 | — | — | US | disclosed |
| WO-2004018483-A1 | FUSED HETEROCYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-03-04 | — | — | WO | disclosed |
| EP-1368358-A1 | ISOXAZOLINE DERIVATIVES AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-12-10 | — | — | EP | disclosed |
| WO-2003076400-A1 | NEW INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-09-18 | — | — | WO | disclosed |
| WO-2002066484-A1 | ISOXAZOLINE DERIVATIVES AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-08-29 | — | — | WO | disclosed |
| US-5561140-A | IMMUNOSUPPRESSANTS; SIDE EFFECT REDUCTION | ABBOTT LABORATORIES (US) | 1996-10-01 | — | — | US | disclosed |
| US-5530119-A | IMMUNOSUPPRESSANTS | ABBOTT LABORATORIES (US) | 1996-06-25 | — | — | US | disclosed |
| EP-0690713-A1 | SUBSTITUTED ALICYCLIC AMINE-CONTAINING MACROCYCLIC IMMUNOMODULATORS | ABBOTT LABORATORIES (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021254-A1 | SUBSTITUTED ALICYCLIC AMINE-CONTAINING MACROCYCLIC IMMUNOMODULATORS | ABBOTT LABORATORIES (US) | 1994-09-29 | — | — | WO | disclosed |
| US-4177272-A | HYPOTENSIVE, VASODILATION, PARKINSON'S DISEASE | SCIENCE UNION ET CIE (FR) | 1979-12-04 | — | — | US | disclosed |
| US-4112092-A | CNS DISORDER, PARKINSON'S, CARDIOVASCULAR DISORDER | SCIENCE UNION ET CIE (FR) | 1978-09-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253627-A1 | TRITERPENE AMINE DERIVATIVES | BET1, PGGT1B, NFATC1 | SLC6A4 3007/4885KMT2A 3133/4885SIGMAR1 1936/4885 |
| US-10093630-B2 | Pyrazole compounds and methods of making and using same | ABHD6, FAAH, FAAH2 | SLC6A4 3345/4885KMT2A 2932/4885SIGMAR1 1237/4885 |
| US-20180360824-A1 | PROCASPASE-ACTIVATING COMPOUNDS AND METHODS | CASP3, CASP5, CASP6 | SLC6A4 4852/4885KMT2A 3185/4885SIGMAR1 4613/4885 |
| US-10022371-B2 | Procaspase-activating compounds and methods | CASP3, CASP5, CASP6 | SLC6A4 4852/4885KMT2A 3185/4885SIGMAR1 4613/4885 |
| US-11236122-B2 | Triterpene amine derivatives | BET1, PGGT1B, NFATC1 | SLC6A4 3007/4885KMT2A 3133/4885SIGMAR1 1936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.