SCHEMBL8535595

SCHEMBL8535595

CC(C)Oc1cccc(C(=O)Nc2ccccc2)c1C(F)(F)F

nearest known ligand 0.62

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KCNK3 O14649 9/20 0.62
KCNK9 Q9NPC2 9/20 0.62
RXFP1 Q9HBX9 5/20 0.60
HTR2A P28223 1/20 0.53
TSPO P30536 1/20 0.53
GPR183 P32249 1/20 0.53
APLNR P35414 1/20 0.53
KMT2A Q03164 1/20 0.47
HPGD P15428 1/20 0.47
SGMS2 Q8NHU3 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10617132 0.83 IRAK4 (0.49) KCNK3KCNK9RXFP1HTR2ATSPO
SCHEMBL1441426 0.81 KCNK3 (0.60) KCNK3KCNK9RXFP1KMT2AHPGD
SCHEMBL11601795 0.80 KCNK3 (0.56) KCNK3KCNK9RXFP1HTR2ATSPO
SCHEMBL20472310 0.79 KCNK3 (0.53) KCNK3KCNK9RXFP1HTR2ATSPO
SCHEMBL5811323 0.77 MEN1 (0.60) KCNK3KCNK9RXFP1KMT2AHPGD
SCHEMBL28799328 0.76 PTGS1 (0.62) KCNK3KCNK9RXFP1KMT2AHPGD
Flutolanil SCHEMBL29451184 0.75 KCNK3 (0.65) KCNK3KCNK9RXFP1HTR2ATSPO
Flutolanil SCHEMBL8362549 0.75 KCNK3 (0.65) KCNK3KCNK9RXFP1HTR2ATSPO
Flutolanil SCHEMBL18555 0.75 KCNK3 (0.65) KCNK3KCNK9RXFP1HTR2ATSPO
SCHEMBL15528728 0.75 RXFP1 (1.00) RXFP1HTR2ATSPOGPR183APLNR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018148224-A1 PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS Seattle Children's Hospital (dba Seattle Children's Research Institute) (US) 2018-08-16 WO claimed
CN-1399885-A N- (1-nitrile-1, 2-dimethyl) -2- (2, 4-dichloro-3-methyl-phenoxy) propionamide bactericidal and insecticidal composition MA YUNSHENG (CN) 2003-03-05 CN claimed
WO-2018148224-A1 PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS Seattle Children's Hospital (dba Seattle Children's Research Institute) (US) 2018-08-16 WO disclosed
CN-107616174-A A kind of composition containing ZJ10520 and acid amide fungicides 浙江省化工研究院有限公司 2018-01-23 CN disclosed
CN-104521989-A Compound composition containing 2-(p-fluorophenyl)-5-methanesulfonyl-1,3,4-oxadiazole and amide bactericides and preparation GAUNGXI TIANYUAN BIOCHEMISTRY 2015-04-22 CN disclosed
CN-103371190-A Pesticide combination containing pyrimidine nucleosides antibiotics SHAANXI WEIERQI CROP PROT CO 2013-10-30 CN disclosed
CN-102057932-B Bactericidal composite containing thiophanate-methyl SHAANXI MEIBANG PESTICIDES CO 2013-08-14 CN disclosed
CN-101755845-B Bactericide composition containing flutolanil FUJIAN SINO DESHING BIOENGINEERING CO LTD 2012-06-27 CN disclosed
CN-102217605-A Sterilizing composition containing flutolanil and triazole compound SHAANXI TANGPUSEN BIOTECH CO 2011-10-19 CN disclosed
CN-102057932-A Bactericidal composite containing thiophanate-methyl SHAANXI MEIBANG PESTICIDE CO 2011-05-18 CN disclosed
CN-101755845-A Bactericide composition containing flutolanil ZHANGYAN CHEN 2010-06-30 CN disclosed
CN-1618287-A Composition of bactericide, germicide and pesticide contg. N-(1-nitrile-1,2-dimethyl)-2-(2,4-dichloro-3-methyl-phenoxy) propionamide MA YUNSHENG (CN) 2005-05-25 CN disclosed
CN-1399885-A N- (1-nitrile-1, 2-dimethyl) -2- (2, 4-dichloro-3-methyl-phenoxy) propionamide bactericidal and insecticidal composition MA YUNSHENG (CN) 2003-03-05 CN disclosed
EP-0639572-B1 2-(2,6-DIFLUOROPHENYL)-4-(2-ETHOXY-4-TERT-BUTYLPHENYL)-2-OXAZOLINE YASHIMA KAGAKU KOGYO KK (JP) 1998-07-29 EP disclosed
EP-0432661-B1 2-Substituted phenyl-2-oxazoline or thiazoline derivatives, process for producing the same and insecticides and acaricides containing the same YASHIMA KAGAKU KOGYO KK (JP) 1996-03-06 EP disclosed
US-5478855-A Miticide YASHIMA CHEMICAL INDUSTRY CO., LTD. (JP) 1995-12-26 US disclosed
EP-0639572-A1 2-(2,6-DIFLUOROPHENYL)-4-(2-ETHOXY-4-TERT-BUTYLPHENYL)-2-OXAZOLINE YASHIMA CHEMICAL INDUSTRY CO., LTD. (JP) 1995-02-22 EP disclosed
US-5141948-A 2-SUBSTITUTED PHENYL-2-OXAZOLINE OR THIAZOLINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND INSECTICIDES AND ACARICIDES CONTAINING THE SAME YASHIMA CHEMICAL INDUSTRIAL CO., LTD. (JP) 1992-08-25 US disclosed
EP-0345775-B1 OXA- OR THIA-ZOLINE DERIVATIVE YASHIMA CHEMICAL INDUSTRIAL CO., LTD. (JP) 1992-04-08 EP disclosed
EP-0345775-A1 Oxa- or thia-zoline derivative YASHIMA CHEMICAL INDUSTRIAL CO., LTD. (JP) 1989-12-13 EP disclosed