Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 3/20 | 0.32 |
| ▸ | PPARA | Q07869 | 3/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152588 | 0.77 | P2RX7 (0.32) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6152831 | 0.75 | HRH1 (0.35) | KDM4E | |
| SCHEMBL7252522 | 0.72 | SLC16A3 (0.34) | — | |
| SCHEMBL6152550 | 0.72 | TDP1 (0.31) | TDP1 | |
| SCHEMBL6152317 | 0.72 | KDM4E (0.34) | KMT2AMEN1POLBLMNAALDH1A1 | |
| SCHEMBL7240668 | 0.71 | HRH1 (0.34) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6151956 | 0.71 | — | — | |
| SCHEMBL7491122 | 0.68 | MEN1 (0.35) | KMT2AMEN1HPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL4756140 | 0.66 | CRHBP (0.35) | KMT2AMEN1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL8049659 | 0.66 | CYP2C9 (0.44) | KMT2AMEN1HPGDLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882044-A1 | 1,4-DIHYDROPYRIDINE COMPOUNDS AS BRADYKININ ANTAGONISTS | PFIZER INC. (US) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997030048-A1 | 1,4-DIHYDROPYRIDINE COMPOUNDS AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 1997-08-21 | — | — | WO | disclosed |