Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 14/20 | 0.45 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | ADK | P55263 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17685265 | 0.79 | TRPV1 (0.49) | TRPV1 | |
| SCHEMBL15624412 | 0.79 | TRPV1 (0.47) | TRPV1EPHX2ADRA1A | |
| SCHEMBL29360220 | 0.77 | CSNK1A1 (0.49) | TAAR1NISCHMTORADKMEN1 | |
| SCHEMBL773131 | 0.77 | CSNK1A1 (0.49) | TAAR1NISCHMTORADKMEN1 | |
| SCHEMBL4764130 | 0.77 | NISCH (0.47) | TRPV1NISCHMTORADKMEN1 | |
| SCHEMBL12987670 | 0.76 | TRPV1 (0.40) | TAAR1TRPV1EPHX2ADRA1A | |
| SCHEMBL7537761 | 0.74 | CSNK1A1 (0.49) | TRPV1NISCHMTORADKMEN1 | |
| SCHEMBL7235096 | 0.73 | TAAR1 (0.49) | TAAR1NISCHMTORADKMEN1 | |
| SCHEMBL6924805 | 0.73 | ADRA2A (0.49) | TAAR1NISCHMTORADKMEN1 | |
| SCHEMBL4765463 | 0.73 | ADRA2A (0.47) | TRPV1NISCHMTORADKMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880504-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-12-02 | — | — | EP | claimed |
| WO-1997027181-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-07-31 | — | — | WO | claimed |
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |