SCHEMBL8536367

SCHEMBL8536367

CC(CCNC(=O)OC(C)(C)C)CCN(CC(=O)O)Cc1cccc2ccccc12

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CTSS P25774 1/20 0.45
CTSK P43235 1/20 0.45
NQO2 P16083 1/20 0.45
NR1D1 P20393 1/20 0.42
FNTA P49354 1/20 0.41
FNTB P49356 1/20 0.41
KCNA5 P22460 1/20 0.40
CKS1B P61024 1/20 0.38
SKP1 P63208 1/20 0.38
SKP2 Q13309 1/20 0.38
PPARG P37231 2/20 0.37
PPARA Q07869 2/20 0.37
CYP3A4 P08684 4/20 0.37
KMT2A Q03164 1/20 0.36
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
HIF1A Q16665 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17018368 0.77 NQO2 (0.48) CTSSCTSKNQO2NR1D1CKS1B
SCHEMBL8329449 0.76 FNTA (0.59) CTSSCTSKNQO2NR1D1FNTA
SCHEMBL8329445 0.76 FNTA (0.59) CTSSCTSKNQO2NR1D1FNTA
SCHEMBL30960252 0.74 DRD2 (0.48) CTSSCTSKNQO2NR1D1CYP3A4
SCHEMBL1579453 0.73 NQO2 (0.75) CTSSCTSKNQO2
SCHEMBL18942412 0.73 TDP1 (0.62) PPARGPPARAKMT2ATDP1HIF1A
SCHEMBL9063268 0.72 KMT2A (0.41) CTSSCTSKKCNA5KMT2ATDP1
SCHEMBL8536361 0.72 CTSK (0.47) CTSSCTSKNQO2NR1D1FNTA
SCHEMBL8536364 0.72 CTSK (0.47) CTSSCTSKNQO2NR1D1FNTA
SCHEMBL23649248 0.71 NQO2 (0.65) CTSSCTSKNQO2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0725650-A4 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO INC (US) 1999-02-03 EP disclosed
US-5585359-A LACK OF THIOL MOIETY PREVENTS THIOL-DEPENDENT CHEMICAL REACTIONS AND REDUCES SYSTEMIC TOXICITY MERCK & CO., INC. (US) 1996-12-17 US disclosed
US-5576293-A TETRAPEPTIDES, ANTICARCINOGENIC AGENTS MERCK & CO., INC. (US) 1996-11-19 US disclosed
EP-0725650-A1 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO. INC. (US) 1996-08-14 EP disclosed
WO-1995009001-A1 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 1995-04-06 WO disclosed