Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.31 |
| ▸ | DUT | P33316 | 2/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201596 | 0.80 | MGAM (0.43) | NPC1RAB9ACACNA1H | |
| SCHEMBL7833147 | 0.74 | NPC1 (0.35) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5214411 | 0.71 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13508627 | 0.70 | KMT2A (0.54) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7464101 | 0.70 | MPO (0.32) | — | |
| SCHEMBL2908964 | 0.68 | CACNA1H (0.37) | NPC1RAB9ASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL7470600 | 0.68 | NPC1 (0.32) | NPC1RAB9ASMN1; SMN2DUT | |
| SCHEMBL18576287 | 0.67 | PDE3B (0.43) | SMN1; SMN2PDE3BPDE3AMAOA | |
| SCHEMBL5864464 | 0.67 | CYP2C9 (0.42) | DUT | |
| SCHEMBL18663573 | 0.67 | GAA (0.56) | RAB9ASMN1; SMN2CACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739345-A | HYPOGLYCEMIC AND ANTIDIABETIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1998-04-14 | — | — | US | disclosed |