SCHEMBL8536723

SCHEMBL8536723

CCCNC(=O)C(F)(F)C(=O)C(NC(=O)Cn1c(-c2ccccc2)ccc(N)c1=O)C(C)C

nearest known ligand 0.78

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ELANE P08246 20/20 0.78
CTRC Q99895 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7547485 0.91 ELANE (0.75) ELANECTRC
SCHEMBL7274370 0.88 ELANE (1.00) ELANECTRC
SCHEMBL7397385 0.87 ELANE (0.68) ELANECTRC
SCHEMBL7490681 0.87 ELANE (0.79) ELANECTRC
SCHEMBL8994538 0.86 ELANE (0.73) ELANECTRC
SCHEMBL8994556 0.86 ELANE (0.68) ELANECTRC
SCHEMBL7552480 0.84 ELANE (0.64) ELANECTRC
SCHEMBL7398785 0.79 CMA1 (0.67) ELANECTRC
SCHEMBL8994544 0.79 ELANE (0.77) ELANECTRC
SCHEMBL7399121 0.79 ELANE (0.73) ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0636142-B1 LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY ZENECA LTD (GB) 1998-06-17 EP claimed
US-5721222-A Heterocyclic ketones ZENECA LIMITED (GB) 1998-02-24 US claimed