Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGFRL1 | Q5TC84 | 7/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 15/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 10/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL852496 | 0.92 | OGFRL1 (0.53) | OGFRL1OPRM1OPRK1OPRD1OPRL1 | |
| SCHEMBL855707 | 0.89 | OGFRL1 (0.39) | OGFRL1OPRM1OPRK1OPRD1OPRL1 | |
| SCHEMBL854261 | 0.84 | OPRM1 (0.40) | OGFRL1OPRM1OPRK1OPRD1OPRL1 | |
| SCHEMBL16714152 | 0.82 | OPRM1 (0.38) | OGFRL1OPRM1OPRK1OPRD1OPRL1 | |
| SCHEMBL854436 | 0.71 | OPRM1 (0.40) | OGFRL1OPRM1OPRK1OPRD1OPRL1 | |
| SCHEMBL880911 | 0.69 | OGFRL1 (0.85) | OGFRL1OPRM1OPRK1OPRD1OPRL1 | |
| SCHEMBL3948931 | 0.64 | OPRM1 (0.63) | OGFRL1OPRM1OPRK1OPRD1OPRL1 | |
| SCHEMBL21548105 | 0.62 | OGFRL1 (0.56) | OGFRL1OPRM1OPRK1OPRD1OPRL1 | |
| SCHEMBL880914 | 0.61 | OGFRL1 (1.00) | OGFRL1OPRM1OPRK1OPRD1OPRL1 | |
| Phenylacetic Acid SCHEMBL27799591 | 0.60 | OPRM1 (0.51) | OGFRL1OPRM1OPRK1OPRD1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564240-A1 | PIPERIDINE INTERMEDIATES | Purdue Pharma L.P. (US) | 2019-11-06 | — | — | EP | disclosed |
| EP-3101018-A1 | SUBSTITUTED-QUINOXALINE-TYPE-PIPERIDINE COMPOUNDS AND THE USES THEREOF | Purdue Pharma L.P. (US) | 2016-12-07 | — | — | EP | disclosed |
| EP-2433937-B1 | Substituted-quinoxaline-type-piperidine compounds and the uses thereof | PURDUE PHARMA LP (US) | 2016-06-29 | — | — | EP | disclosed |
| EP-2433937-A1 | Substituted-quinoxaline-type-piperidine compounds and the uses thereof | Purdue Pharma LP (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-2433935-A1 | Substituted-quinoxaline-type-piperidine compounds and the uses thereof | Purdue Pharma LP (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-2433936-A1 | Substituted-quinoxaline-type-piperidine compounds and the uses thereof | Purdue Pharma LP (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-2086958-A2 | SUBSTITUTED-QUINOXALINE-TYPE-PIPERIDINE COMPOUNDS AND THE USES THEREOF | Purdue Pharma LP (US) | 2009-08-12 | — | — | EP | disclosed |
| WO-2009027820-A2 | SUBSTITUTED-QUINOXALINE-TYPE-PIPERIDINE COMPOUNDS AND THE USES THEREOF | PURDUE PHARMA L.P. (DE) | 2009-03-05 | — | — | WO | disclosed |