Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.72 |
| ▸ | RAB9A | P51151 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | CYP27B1 | O15528 | 2/20 | 0.59 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.54 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.54 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.53 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3224949 | 0.85 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2KDM4ETAAR1 | |
| SCHEMBL13495002 | 0.85 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2KDM4ETAAR1 | |
| SCHEMBL5739087 | 0.79 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2CYP27B1CYP24A1 | |
| SCHEMBL5260012 | 0.79 | UTS2R (0.53) | NPC1RAB9ASMN1; SMN2CYP27B1CYP24A1 | |
| SCHEMBL1568754 | 0.78 | RAB9A (0.79) | NPC1RAB9ASMN1; SMN2KDM4ETAAR1 | |
| SCHEMBL5177202 | 0.77 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4253132 | 0.77 | SMO (0.70) | NPC1RAB9ASMN1; SMN2KDM4ETAAR1 | |
| SCHEMBL8536903 | 0.77 | KDM4E (0.51) | CYP27B1CYP24A1KDM4ESLC6A9SLC6A5 | |
| SCHEMBL28644570 | 0.76 | RAB9A (0.54) | NPC1RAB9ASMN1; SMN2CYP27B1CYP24A1 | |
| SCHEMBL28644572 | 0.76 | RAB9A (0.54) | NPC1RAB9ASMN1; SMN2CYP27B1CYP24A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683156-B1 | Acylated aminoalkanimidazoles and -triazoles | CIBA GEIGY AG (CH) | 1998-04-01 | — | — | EP | disclosed |
| US-5622982-A | ENZYME INHIBITORS; ANTIINFLAMMATORY AGENTS | SANDOZ LTD. (CH) | 1997-04-22 | — | — | US | disclosed |
| EP-0683156-A1 | Acylated aminoalkanimidazoles and -triazoles | SANDOZ LTD. (CH) | 1995-11-22 | — | — | EP | disclosed |