Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 9/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.33 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | RGS12 | O14924 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL941036 | 0.72 | TSHR (0.41) | GAAADAMTS5ALDH1A1KMT2AADAM17 | |
| SCHEMBL23877959 | 0.72 | TSHR (0.41) | GAAADAMTS5ALDH1A1KMT2AADAM17 | |
| SCHEMBL9854417 | 0.72 | TSHR (0.41) | GAAADAMTS5ALDH1A1KMT2AADAM17 | |
| SCHEMBL855469 | 0.70 | GAA (0.37) | GAAADAMTS5ALDH1A1KMT2AADAM17 | |
| SCHEMBL4621026 | 0.69 | TSHR (0.43) | GAAADAMTS5ALDH1A1KMT2AADAM17 | |
| SCHEMBL561443 | 0.65 | — | — | |
| SCHEMBL9402142 | 0.65 | — | — | |
| SCHEMBL337478 | 0.65 | GAA (0.56) | GAAADAMTS5ALDH1A1KMT2AADAMTS4 | |
| SCHEMBL5620774 | 0.65 | GAA (0.56) | GAAADAMTS5ALDH1A1KMT2AADAMTS4 | |
| SCHEMBL11352404 | 0.65 | TSHR (0.46) | GAAADAMTS5ALDH1A1KMT2AADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420683-B2 | 5 substituted hydantoins | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2013-04-16 | — | — | US | disclosed |
| EP-2150538-B1 | NOVEL 5-SUBSTITUTED HYDANTOINS | DSM SINOCHEM PHARM NL BV (NL) | 2012-03-28 | — | — | EP | disclosed |
| US-20100174092-A1 | NOVEL 5 SUBSTITUTED HYDANTOINS | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2010-07-08 | — | — | US | disclosed |
| EP-2150538-A2 | NOVEL 5-SUBSTITUTED HYDANTOINS | DSM IP Assets B.V. (NL) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008148755-A2 | NOVEL 5-SUBSTITUTED HYDANTOINS | DSM IP ASSETS B.V. (NL) | 2008-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100174092-A1 | NOVEL 5 SUBSTITUTED HYDANTOINS | CYP3A5, REN, ACE | GAA 2157/4885ADAMTS5 1271/4885ALDH1A1 200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.