Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2632364 | 0.90 | LMNA (0.60) | LMNAAOC3HTR2AHTR2CHTR7 | |
| SCHEMBL14569262 | 0.90 | LMNA (0.60) | LMNAAOC3HTR2AHTR2CHTR7 | |
| SCHEMBL1978021 | 0.90 | LMNA (0.60) | LMNAAOC3HTR2AHTR2CHTR7 | |
| SCHEMBL9607168 | 0.82 | LMNA (0.69) | LMNAAOC3MEN1KMT2AKDM4E | |
| SCHEMBL1607138 | 0.78 | LMNA (0.75) | LMNAAOC3TDP1KDM4EALDH1A1 | |
| SCHEMBL9607473 | 0.78 | LTA4H (0.53) | LMNAAOC3ALDH1A1 | |
| SCHEMBL3917902 | 0.77 | LMNA (0.60) | LMNATDP1ALDH1A1TRPA1TAAR1 | |
| SCHEMBL10397242 | 0.77 | AOC3 (0.52) | AOC3HTR2AHTR2CHTR7KDM4E | |
| SCHEMBL3917903 | 0.77 | LMNA (0.60) | LMNATDP1ALDH1A1TRPA1TAAR1 | |
| SCHEMBL9607167 | 0.76 | PDE2A (0.48) | LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |