SCHEMBL8537384

SCHEMBL8537384

COC(=O)c1cccnc1CN1C(=O)C(N)N=C(c2ccccc2F)c2ccccc21

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCKBR P32239 14/20 0.43
CCKAR P32238 13/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8537391 1.00 CCKBR (0.43) CCKBRCCKAR
SCHEMBL8535401 0.90 CCKBR (0.42) CCKBRCCKAR
SCHEMBL8535409 0.90 CCKBR (0.42) CCKBRCCKAR
SCHEMBL8537754 0.89 CCKBR (0.41) CCKBRCCKAR
SCHEMBL8775246 0.89 CCKBR (0.41) CCKBRCCKAR
SCHEMBL8535348 0.85 TP53 (0.42) CCKBRCCKAR
SCHEMBL8535344 0.85 TP53 (0.42) CCKBRCCKAR
SCHEMBL8773977 0.84 PRMT5 (0.39) CCKBRCCKAR
SCHEMBL8537665 0.84 PRMT5 (0.39) CCKBRCCKAR
SCHEMBL8588799 0.84 CCKBR (0.41) CCKBRCCKAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5763437-A Benzodiazepine derivatives FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-06-09 US disclosed